Remapping and realignment in the human hippocampal formation predict context-dependent spatial behavior
Remapping and realignment in the human hippocampal formation predict context-dependent spatial behavior
复制标题
人类海马结构的重新映射和重新排列可以预测上下文相关的空间行为
DOI：
10.1038/s41593-021-00835-3
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发表时间：
2021-04-15
影响因子：
25
通讯作者：
Doeller, Christian F.
中科院分区：
文献类型：
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作者：
Julian, Joshua B.;Doeller, Christian F.
Julian和Doeller的研究表明，在人类大脑中，对地图样表征的一次又一次的调制，可以预测在虚拟现实导航过程中的情境记忆提取，而不依赖于视觉体验，为了指导空间行为，大脑必须提取与不同导航情境相关联的记忆。背景记忆可能是由海马结构中的细胞群介导的，这些细胞群改变了它们对背景变化的反应，这一过程分别被称为海马和内嗅皮层的重新映射和重新排列。然而，重新映射和重新排列是否指导上下文相关的空间行为尚不清楚。为了解决这个问题，人类参与者在两个不同的虚拟现实环境中学习物体位置关联，随后在功能性MRI（fMRI）扫描期间测试他们的记忆。内嗅网格状表示显示两种情况之间的重新排列，并在海马中观察到与重新映射一致的fMRI活动模式的一致变化。至关重要的是，在第三个模糊的背景下，在大脑-内嗅网络中，一次又一次的重新映射和重新排列预测了情境依赖性行为。这些结果揭示了介导人类情境记忆的海马-内嗅机制，并表明海马结构在不确定条件下的空间行为中起着关键作用。
Julian and Doeller show that trial-by-trial modulation of map-like representations in the human hippocampal-entorhinal system predicts contextual memory retrieval during virtual reality navigation independent of visual experience.To guide spatial behavior, the brain must retrieve memories that are appropriately associated with different navigational contexts. Contextual memory might be mediated by cell ensembles in the hippocampal formation that alter their responses to changes in context, processes known as remapping and realignment in the hippocampus and entorhinal cortex, respectively. However, whether remapping and realignment guide context-dependent spatial behavior is unclear. To address this issue, human participants learned object-location associations within two distinct virtual reality environments and subsequently had their memory tested during functional MRI (fMRI) scanning. Entorhinal grid-like representations showed realignment between the two contexts, and coincident changes in fMRI activity patterns consistent with remapping were observed in the hippocampus. Critically, in a third ambiguous context, trial-by-trial remapping and realignment in the hippocampal-entorhinal network predicted context-dependent behavior. These results reveal the hippocampal-entorhinal mechanisms mediating human contextual memory and suggest that the hippocampal formation plays a key role in spatial behavior under uncertainty.