The two major isoforms of thyroid hormone receptor, TRα1 and TRβ1, preferentially partner with distinct panels of auxiliary proteins.
The two major isoforms of thyroid hormone receptor, TRα1 and TRβ1, preferentially partner with distinct panels of auxiliary proteins.
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甲状腺激素受体的两种主要亚型 TRα1 和 TRβ1 优先与不同的辅助蛋白组结合。
DOI：
10.1016/j.mce.2013.11.015
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发表时间：
2014
影响因子：
4.1
通讯作者：
Privalsky,MartinL
中科院分区：
文献类型：
--
作者：
Hahm,JohnnieB;Schroeder,AmyC;Privalsky,MartinL
甲状腺激素受体(TRs)主要以两种主要亚型--α-1和β-1在成人发育的不同时期和不同的组织丰度中表达。Trα1和trβ1的转录特性和生物学特性可以不同。我们在这里报道，虽然重叠，但trα1和trβ1招募了不同的伙伴蛋白面板，这可能是它们不同的生物学功能的原因，并似乎解释了它们不同的靶基因调节特性。
Thyroid hormone receptors (TRs) are expressed primarily as two major isoforms, TRα1 and TRβ1, which are expressed at different times in development and at different tissue abundances in the adult. The transcription properties and biological properties of TRα1 and TRβ1 can differ. We report here that although overlapping, TRα1 and TRβ1 recruit distinct panels of partner proteins that may account for their divergent biological functions, and which appear to explain their distinct target gene regulatory properties.