Mortality following Campylobacter infection: a registry-based linkage study.
Mortality following Campylobacter infection: a registry-based linkage study.
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DOI：
10.1186/1471-2334-5-70
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发表时间：
2005-09-14
影响因子：
3.7
通讯作者：
Ekdahl K
中科院分区：
文献类型：
--
作者：
Ternhag A;Törner A;Svensson A;Giesecke J;Ekdahl K
弯曲杆菌病是最常见的细菌性腹泻病的原因之一，也是发达国家旅行者胃肠炎的常见原因。尽管广泛发生，但关于弯曲杆菌死亡率的信息很少。将弯曲杆菌病例队列中的死亡率与发病后0-1、1-3、3-12和12个月以上的普通人群进行比较。根据这些病例是在国内还是在国外感染，对它们进行了分组。在发病后第一个月内，国内感染病例的标准化死亡率为2.9（95% CI：1.9-4.0）。然后风险逐渐降低，并在患病一年或更长时间后接近1.0。这种最初的过度风险并不归因于任何特定的年龄组（如最老的）。相比之下，对于那些在国外感染的人，诊断后第一个月的标准化死亡率为0.3（95% CI：0.04-0.8），低于一般人群的预期。弯曲杆菌感染与那些在国内感染的人的短期死亡风险增加有关。相反，对于在国外感染的人来说，死亡风险显然低于预期。我们认为这背后的解释是输入病例中的“健康旅行者效应”，以及国内病例中比平均人群更虚弱的效应。
Campylobacteriosis is one of the most commonly identified causes of bacterial diarrheal disease and a common cause of gastroenteritis in travellers from developed nations. Despite the widespread occurrence, there is little information on Campylobacter mortality. Mortality among a cohort of Campylobacter cases were compared with the general population 0–1, 1–3, 3–12 and more than 12 month after the onset of the illness. The cases were sub-grouped according to if they had been infected domestically or abroad. The standardized mortality ratio for cases infected domestically was 2.9 (95% CI: 1.9–4.0) within the first month following the illness. The risk then gradually diminished and approached 1.0 after one year or more have passed since the illness. This initial excess risk was not attributable to any particular age group (such as the oldest). In contrast, for those infected abroad, a lower standardized mortality ratio 0.3 (95% CI: 0.04–0.8) was shown for the first month after diagnosis compared to what would be expected in the general population. Infection with Campylobacter is associated with an increased short-term risk of death among those who were infected domestically. On the contrary, for those infected abroad a lower than expected risk of death was evident. We suggest that the explanation behind this is a "healthy traveler effect" among imported cases, and effects of a more frail than average population among domestic cases.