Choanal atresia associated with prenatal methimazole exposure: Three new patients
Choanal atresia associated with prenatal methimazole exposure: Three new patients
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与产前甲硫咪唑暴露相关的后鼻孔闭锁：三名新患者
DOI：
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发表时间：
2004
期刊：
影响因子：
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通讯作者：
M. Torrado
中科院分区：
文献类型：
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作者：
P. Barbero;C. Ricagni;G. Mercado;R. Bronberg;M. Torrado
我们报告了三例出生前暴露于甲巯咪唑（MMI）的儿童双侧后鼻孔闭锁，以确定MMI胚胎病的临床模式。后鼻孔闭锁和其他特定畸形的组合非常类似于先前报道的子宫内暴露于MMI的患者。目前，丙基硫氧嘧啶被认为是怀孕期间最好的治疗方法。然而，在阿根廷和其他一些国家，MMI是唯一的抗甲状腺药物，可能对未出生的胎儿构成重大风险。© 2004 Wiley利斯公司
We report three patients with bilateral choanal atresia in children prenatally exposed to methimazole (MMI) in order to define a MMI embryopathy clinical pattern. The combination of choanal atresia and other specific malformations strongly resembles previously reported patients exposed to MMI in utero. At present, propylthiouracil is considered the best treatment in pregnancies. However in Argentina and some other countries MMI is the only antithyroid drug, possibly posing a significant risk to the unborn fetus. © 2004 Wiley‐Liss, Inc.