Hypoxia-dependent drivers of melanoma progression.
Hypoxia-dependent drivers of melanoma progression.
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黑色素瘤进展的缺氧依赖性驱动因素。
DOI：
10.1186/s13046-021-01926-6
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发表时间：
2021-05-08
期刊：
影响因子：
--
通讯作者：
Moramarco A
中科院分区：
文献类型：
--
作者：
D'Aguanno S;Mallone F;Marenco M;Del Bufalo D;Moramarco A
缺氧是一种低氧可用性的状况，是肿瘤微环境的标志，并促进癌症进展和对治疗的抵抗。许多研究报道了缺氧在调节黑色素瘤的侵袭性、血管生成、血管生成拟态和治疗反应中的重要作用。黑色素瘤是一种侵袭性癌症，起源于位于皮肤（皮肤黑色素瘤）、眼睛的葡萄膜（葡萄膜黑色素瘤）或粘膜（粘膜黑色素瘤）中的黑色素细胞。黑色素瘤的这三种亚型在生物学、流行病学、病因学、分子特征和临床特征方面代表不同的肿瘤。本文就缺氧调节黑色素瘤各亚型发生发展的相关通路的最新研究进展进行综述。我们还总结了目前的知识与缺氧诱导因子-1，血管生成或血管生成拟态靶向药物的临床前研究。最后，我们描述了临床研究的现有证据，这些研究调查了缺氧诱导因子-1抑制剂或抗血管生成药物单独或与其他策略联合用于皮肤、葡萄膜和粘膜黑色素瘤的转移性和辅助治疗。据报道，缺氧诱导因子非依赖性途径也可以调节黑色素瘤的进展，但这个问题超出了本文的范围。从本综述中讨论的众多研究中可以看出，对黑色素瘤进展中缺氧调节途径的认识不断增加，以及从新型抗血管生成疗法中获得的有希望的结果，可以为临床实践提供新的视角，以改善黑色素瘤患者的生存结局。
Hypoxia, a condition of low oxygen availability, is a hallmark of tumour microenvironment and promotes cancer progression and resistance to therapy. Many studies reported the essential role of hypoxia in regulating invasiveness, angiogenesis, vasculogenic mimicry and response to therapy in melanoma. Melanoma is an aggressive cancer originating from melanocytes located in the skin (cutaneous melanoma), in the uveal tract of the eye (uveal melanoma) or in mucosal membranes (mucosal melanoma). These three subtypes of melanoma represent distinct neoplasms in terms of biology, epidemiology, aetiology, molecular profile and clinical features. In this review, the latest progress in hypoxia-regulated pathways involved in the development and progression of all melanoma subtypes were discussed. We also summarized current knowledge on preclinical studies with drugs targeting Hypoxia-Inducible Factor-1, angiogenesis or vasculogenic mimicry. Finally, we described available evidence on clinical studies investigating the use of Hypoxia-Inducible Factor-1 inhibitors or antiangiogenic drugs, alone or in combination with other strategies, in metastatic and adjuvant settings of cutaneous, uveal and mucosal melanoma. Hypoxia-Inducible Factor-independent pathways have been also reported to regulate melanoma progression, but this issue is beyond the scope of this review. As evident from the numerous studies discussed in this review, the increasing knowledge of hypoxia-regulated pathways in melanoma progression and the promising results obtained from novel antiangiogenic therapies, could offer new perspectives in clinical practice in order to improve survival outcomes of melanoma patients.
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影响因子：
8.4
作者：
Ascierto, Paolo A.;Dummer, Reinhard;Robert, Caroline
通讯作者：
Robert, Caroline
影响因子：
2.2
作者：
Angel Martinez-Garcia, Miguel;Riveiro-Falkenbach, Erica;Gozal, David
通讯作者：
Gozal, David
影响因子：
254.7
作者：
Amin, Mahul B.;Greene, Frederick L.;Winchester, David P.
通讯作者：
Winchester, David P.
DOI：
10.1007/s10555-017-9663-3
发表时间：
2017-03
期刊：
Cancer metastasis reviews
影响因子：
--
作者：
Amaro A;Gangemi R;Piaggio F;Angelini G;Barisione G;Ferrini S;Pfeffer U
通讯作者：
Pfeffer U
影响因子：
8.8
作者：
Algazi, A. P.;Cha, E.;Ortiz-Urda, S. M.;McCalmont, T.;Bastian, B. C.;Hwang, J.;Pampaloni, M. H.;Behr, S.;Chong, K.;Cortez, B.;Quiroz, A.;Coakley, F.;Liu, S.;Daud, A. I.
通讯作者：
Daud, A. I.