Effects of L-DOPA/carbidopa administration on the levels of L-DOPA, other amino acids and related compounds in the plasma, brain and heart of the rat
Effects of L-DOPA/carbidopa administration on the levels of L-DOPA, other amino acids and related compounds in the plasma, brain and heart of the rat
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DOI：
10.1159/000139518
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发表时间：
1997-09-01
期刊：
影响因子：
3.1
通讯作者：
Vogel, WH
中科院分区：
文献类型：
--
作者：
Diederich, C;Milakofsky, L;Vogel, WH
用250 mg/kg L-DOPA和40 mg/kg卡比多巴的混合物或载体腹膜内处理大鼠，30分钟后处死。从每只动物中取出血浆、心脏和皮质、中脑、脑干和小脑，并通过HPLC测定L-DOPA和大量氨基酸和相关氨基化合物。左旋多巴水平从检测不到（
Rats were treated intraperitoneally with a mixture of 250 mg/kg L-DOPA and 40 mg/kg carbidopa or with vehicle and sacrificed 30 min later. Plasma, heart and cortex, midbrain, brainstem and cerebellum were removed from each animal and assayed by HPLC for L-DOPA and a large number of amino acids and related amino compounds. L-DOPA levels increased from undetectable (