Integration of macro circulation and micro hemodynamics in the human body for physiological diagnosis and simulation
Integration of macro circulation and micro hemodynamics in the human body for physiological diagnosis and simulation
复制标题
整合人体宏观循环和微观血流动力学进行生理诊断和模拟
DOI：
10.1109/icsmc.2003.1245698
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发表时间：
2003
期刊：
影响因子：
--
通讯作者：
T. Kitamura
中科院分区：
文献类型：
--
作者：
K. Asami;T. Kitamura
本研究的目的是描述一种如何在临床应用中实现心血管系统的生理模拟和诊断的方法。循环系统模型旨在基于实验测量来表示各种变化或疾病。在某些设计水平方面，循环系统可以被建模为大小、分辨率或时间尺度的目标粒度。宏观模型包含全身内各个子系统的广泛生理信息，但不可能将时间相关变量细化到小的时间单位。而微观模型由于忽略了整体的额外功能，因此只能分析单个子系统的微观行为。因此，所提出的生理模拟方法集成了宏观循环和微观心血管系统模型，从而可以同时模拟长期宏观身体状况和短期微观血流。
The purpose of this study is to describe a method of how physiological simulation and diagnosis for the cardiovascular system can be achieved in clinical use. The circulatory system model aims to represent various changes or diseases based on experimental measurements. In respect with some designed levels, the circulatory system could be modeled into a target granularity of sizes, resolutions, or timescales. The macro model contains a wide range of physiological information for various subsystems within the whole body, but it is impossible to be detailed into small time units for time-dependent variables. Whereas, the micro model enables to analyze microscopic behavior only for a single subsystem, because the extrafunctions of the whole body are omitted. Therefore, the proposed physiological simulation method integrates macro circulatory and micro cardiovascular system models, so that long-term macroscopic body conditions and short-term microscopic blood flow could be concurrently simulated.