A Thiopyranchromenone and Other Chromone Derivatives from an Endolichenic Fungus, Preussia africana
A Thiopyranchromenone and Other Chromone Derivatives from an Endolichenic Fungus, Preussia africana
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DOI：
10.1021/np2009362
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发表时间：
2012-02-01
影响因子：
5.1
通讯作者：
Che, Yongsheng
中科院分区：
文献类型：
--
作者：
Zhang, Fan;Li, Li;Che, Yongsheng
天然存在的硫代吡喃色烯酮的第一个例子，preussochromone A（1），和其他五种新的色酮衍生物，preussochromones B-F（2-6），是从一种内生地衣真菌Preussia africana的固体培养物中分离出来的。化合物1-6的结构通过核磁共振实验初步确定，化合物2和4的结构通过X射线晶体学进一步确定。1和2的绝对构型由电子圆二色性（ECD）确定，而3中的C-5、4中的C-6和5中的6，7-二醇的绝对构型分别由原位形成的[Rh-2（OCOCF 3）（4）]配合物的CD数据、改进的Mosher方法和Snatzke方法推断。化合物1和3对A549细胞具有明显的细胞毒性。
The first example of a naturally occurring thiopyranchromenone, preussochromone A (1), and five other new chromone derivatives, preussochromones B-F (2-6), were isolated from solid cultures of an endolichenic fungus, Preussia africana. The structures of 1-6 were established primarily by NMR experiments, and 2 and 4 were further confirmed by X-ray crystallography. The absolute configurations of 1 and 2 were determined by the application of electronic circular dichroism (ECD), whereas those of C-5 in 3, C-6 in 4, and the 6,7-diol in 5 were deduced via the CD data of the in situ formed [Rh-2(OCOCF3)(4)] complex, the modified Mosher method, and Snatzke's method, respectively. Compounds 1 and 3 showed significant cytotoxicity against A549 cells.