Aβ-Degrading Proteases: Therapeutic Potential in Alzheimer Disease.
Aβ-Degrading Proteases: Therapeutic Potential in Alzheimer Disease.
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作者：
The amyloid ß-protein (Aß) is well established to play an indispensible role in the pathogenesis of Alzheimer disease (AD). Aβ is subject to proteolytic degradation by a diverse array of peptidases and proteinases, known collectively as Aβ-degrading proteases (AβDPs). A growing number of AβDPs have been identified, which impact Aß powerfully and in a surprising variety of ways. As such, AßDPs hold considerable therapeutic potential for the treatment and/or prevention of AD. Here we critically review the relative merits of therapeutic strategies targeting AßDPs as compared to current Aß-lowering strategies focused on immunotherapies and pharmacological modulation of Aß-producing enzymes. Several innovative advances have increased considerably the feasibility of delivering AßDPs to the brain or enhancing their activity in a non-invasive manner. We argue that therapies targeting AßDPs offer numerous potential advantages, which should be explored through continued research into this promising field.
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影响因子：
3.7
作者：
Cabrol C;Huzarska MA;Dinolfo C;Rodriguez MC;Reinstatler L;Ni J;Yeh LA;Cuny GD;Stein RL;Selkoe DJ;Leissring MA
通讯作者：
Leissring MA
DOI：
10.1093/brain/awt308
发表时间：
2014-02
期刊：
Brain : a journal of neurology
影响因子：
--
作者：
Henderson SJ;Andersson C;Narwal R;Janson J;Goldschmidt TJ;Appelkvist P;Bogstedt A;Steffen AC;Haupts U;Tebbe J;Freskgård PO;Jermutus L;Burrell M;Fowler SB;Webster CI
通讯作者：
Webster CI
影响因子：
5.4
作者：
De Strooper, Bart;Iwatsubo, Takeshi;Wolfe, Michael S.
通讯作者：
Wolfe, Michael S.
影响因子：
2.8
作者：
Bae, SJ;Matsunaga, Y;Katayama, I
通讯作者：
Katayama, I
影响因子：
7.3
作者：
Abdul-Hay, Samer O.;Lane, Amy L.;Leissring, Malcolm A.
通讯作者：
Leissring, Malcolm A.