Ishitobi Y, Nakayama S, Kanehisa M, Higuma H, Maruyama Y, Okamoto S, Inoue A, Imanaga J, Tanaka Y, Tsuru J, Hanada H, Akiyoshi J.
Ishitobi Y, Nakayama S, Kanehisa M, Higuma H, Maruyama Y, Okamoto S, Inoue A, Imanaga J, Tanaka Y, Tsuru J, Hanada H, Akiyoshi J.
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Ishitobi Y、Nakayama S、Kanehisa M、Higuma H、Maruyama Y、Okamoto S、Inoue A、Imanaga J、Tanaka Y、Tsuru J、Hanada H、Akiyoshi J。
DOI：
10.1097/ypg.0000000000000002
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发表时间：
2013
期刊：
影响因子：
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通讯作者：
Association between corticotropin-releasing hormone receptor 1 and 2 (CRHR1 and CRHR2) gene polymorphisms and personality traits.
中科院分区：
文献类型：
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作者：
Tamura A;Maruyama Y;Ishitobi Y;Kawano A;Ando T;Ikeda R;Inoue A;Imanaga J;Okamoto S;Kanehisa M;Ninomiya T;Tanaka Y;Tsuru J;Akiyoshi J.;Association between corticotropin-releasing hormone receptor 1 and 2 (CRHR1 and CRHR2) gene polymorphisms and personality traits.
此前的研究报告称，下丘脑-垂体-肾上腺轴与人格特征有关。我们研究了促肾上腺皮质激素释放激素受体(CRHR)基因与人格特征之间的关系。采用TaqMan聚合酶链式反应技术，对218名健康志愿者CRHR基因内含子12个单核苷酸多态性(CRHR1和CRHR2各6个)进行了分析。使用修订的新人格问卷、气质和性格问卷以及状态-特质焦虑问卷对人格特征进行评估。未观察到CRHR1和CRHR2的表达与人格特征显著相关。这些结果未能支持CRHR1和CRHR2与日本成年人的人格特征之间的联系。
Previous studies have reported that the hypothalamic–pituitary–adrenal axis is involved with personality traits. We examined the association between corticotropin-releasing hormone receptor (CRHR) genes and personality traits. We investigated the 12 single-nucleotide polymorphisms of intron CRHR (six in CRHR1 and six in CRHR2, respectively) in 218 healthy volunteers using TaqMan PCR assays. Personality traits were assessed using the Revised NEO-Personality Inventory, the Temperament and Character Inventory, and the State-Trait Anxiety Inventory. No significant associations were observed between CRHR1 and CRHR2 expression and personality traits. These results fail to provide support for an association of CRHR1 and CRHR2 with personality traits in a Japanese adult population.