Sleep Timing and Circadian Phase in Delayed Sleep Phase Syndrome
Sleep Timing and Circadian Phase in Delayed Sleep Phase Syndrome
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DOI：
10.1177/0748730409339611
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发表时间：
2009-08-01
影响因子：
3.5
通讯作者：
Zee, Phyllis C.
中科院分区：
文献类型：
--
作者：
Chang, Anne-Marie;Reid, Kathryn J.;Zee, Phyllis C.
睡眠相位延迟综合征（DSPS）是一种昼夜节律睡眠障碍，其中睡眠事件的时间发生晚于期望的时间，并且与入睡困难、按时醒来的问题（例如，失眠）有关。例如，在一个实施例中，以满足工作或学校的义务），和白天嗜睡。睡眠时间和内源性昼夜节律之间的相位关系对于睡眠的启动和维持至关重要，并且显著改变会导致睡眠质量和持续时间的损害。本回顾性研究的目的是确定临床DSPS患者的睡眠-觉醒时间与昼夜节律生理标志物之间的相位关系。对DSPS患者的睡眠时间和昼夜节律相位标志物（核心体温和褪黑激素）进行客观和主观测量，并与年龄匹配的对照组进行比较。正如预期的那样，在DSPS组中，当允许按自己的习惯时间表睡觉时，主要睡眠事件和体温昼夜节律相位以及褪黑激素节律的时间显著延迟，但两组之间的睡眠-觉醒时间和昼夜节律相位之间的相位关系相似。这些结果表明，在现实生活条件下生活的DSPS患者的失眠和白天过度嗜睡的症状不能解释的睡眠-觉醒模式和其他生理昼夜节律之间的相位关系的改变。
Delayed sleep phase syndrome (DSPS) is a circadian rhythm sleep disorder in which the timing of the sleep episode occurs later than desired and is associated with difficulty falling asleep, problems awakening on time (e. g., to meet work or school obligations), and daytime sleepiness. The phase relationship between the timing of sleep and endogenous circadian rhythms is critical to the initiation and maintenance of sleep, and significant alteration leads to impairment of sleep quality and duration. The aim of this retrospective study was to determine the phase relationship between sleep-wake times and physiological markers of circadian timing in clinic patients with DSPS. Objective and subjective measures of sleep timing and circadian phase markers (core body temperature and melatonin) were measured in patients with DSPS and compared with age-matched controls. As expected, significant delays in the timing of the major sleep episode and circadian phase of body temperature and melatonin rhythms were seen in the DSPS group when allowed to sleep at their own habitual schedules, but the phase relationship between sleep-wake times and circadian phase was similar between the 2 groups. These results suggest that the symptoms of insomnia and excessive daytime sleepiness in DSPS patients living under entrained real-life conditions cannot be explained by an alteration in the phase relationship between sleep-wake patterns and other physiological circadian rhythms.