The isolation and structure elucidation of a new sesquiterpene lactone from the poisonous plant Coriaria japonica (Coriariaceae)
The isolation and structure elucidation of a new sesquiterpene lactone from the poisonous plant Coriaria japonica (Coriariaceae)
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DOI：
10.1248/cpb.53.1040
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发表时间：
2005-08-01
影响因子：
1.7
通讯作者：
Takeya, K
中科院分区：
文献类型：
--
作者：
Kinoshita, T;Itaki, N;Takeya, K
从马桑科（Coriariaceae）沿着马桑（Coriariajaponica）的瘦果（种子）中分离得到一个新的倍半萜内酯化合物马桑苷（Coriarin），并与已知成分tutin、dihydrotutin和corianin进行了结构鉴定。马桑苷的结构最终通过碱催化的化学转化来证实，其中内酯环连接从C-3转移到C-2。同时也对肉果进行了化学研究，但没有得到倍半萜内酯或相关成分。结果表明，倍半萜内酯只存在于丁香的瘦果中。日本浆果，就像其他马桑属物种一样。
A new sesquiterpene lactone named coriarin was isolated from achenes (seeds) of Coriaria japonica (Coriariaceae) along with known constituents tutin, dihydrotutin and corianin, and its structure was deduced on a spectroscopic basis. The structure of coriarin was finally confirmed by the base-catalized chemical conversion of tutin into coriarin, in which the lactone ring linkage was transposed from C-3 to C-2. Chemical investigation of sarcocarps was also undertaken in parallel, but neither sesquiterpene lactones nor related constituents were obtained. The results indicate that sesquiterpene lactones occur only in achenes of C. japonica berry, as is the case in other Coriaria species.