Serum PCB levels and congener profiles among US construction workers.
Serum PCB levels and congener profiles among US construction workers.
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DOI：
10.1186/1476-069x-6-25
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发表时间：
2007-08-31
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砖石建筑中发现的填缝（密封剂）材料中存在多氯联苯，这在多个国家都有详细记录。最近对大波士顿地区 24 栋建筑的调查发现，其中 8 栋建筑的窗框周围和砖石块之间的接缝所使用的填缝材料中 PCB 含量较高。研究表明，清除填缝材料的工人血清 PCB 水平升高。该项目将大波士顿地区建筑物中安装和/或拆除含 PCB 填缝材料的男性工人的血清 PCB 水平与同一地区 358 名男性的参考血清 PCB 水平进行了比较。在同一实验室通过液-液萃取、柱色谱净化和双毛细管柱 GC/microECD 分析测量血清 PCB 水平。当比较参考人群和建筑工人之间的同类物概况时，建筑工人中挥发性更强、较轻的 PCB（二氯、三氯和四氯，IUPAC# 6-74 的总和）的血清水平明显更高。在所有 6 名工人中，其中一名最年轻的工人的血清总 PCB 水平（57 种同系物之和）最低，但挥发性更强（氯化程度较低）的 PCB 同系物（#16、26、28、33、74、66 和 60）的贡献明显高于其他 5 名工人和参考男性。在采血时，只有这名工人正在进行去除 PCB 填缝的工作。虽然这项试点研究的结果是基于少量数据（6 名处理 PCB 填缝的建筑工人），但建筑工人的血清 PCB 水平超出了参考值。同类资料的比较表明，建筑工人和一般人群样本之间存在显着差异。这些差异以及建筑工人概况的相似性强烈表明，与填缝材料的职业接触可能是建筑工人接触 PCB 的主要来源。
The presence of PCB in caulking (sealant) material found in masonry buildings has been well-documented in several countries. A recent investigation of 24 buildings in the greater Boston area found that 8 buildings had high PCB levels in caulking materials used around window frames and in joints between masonry blocks. Workers removing caulking material have been shown to have elevated serum PCB levels. This project compared serum PCB levels among male workers who installed and/or removed PCB-containing caulking material from buildings in the greater Boston area with reference serum PCB levels from 358 men from the same area. Serum PCB levels were measured in the same laboratory by liquid-liquid extraction, column chromatography clean-up and dual capillary column GC/microECD analysis. When the congener profiles were compared between the reference population and the construction workers, the serum levels of the more volatile, lighter PCBs (di-, tri-and tetrachloro, sum of IUPAC# 6–74) were substantially higher among the construction workers. One of the youngest workers had the lowest total serum PCB levels (sum of 57 congeners) of all 6 workers, but the contribution of more volatile (less chlorinated) PCB congeners (#16, 26,28,33,74,66, and 60) was markedly higher than in other 5 workers and reference men. Only this worker was working on a job that involved removing PCB caulking at the time of the blood sampling. While the results of this pilot study are based upon small numbers (6 construction workers who handled PCB caulking), the serum PCB levels among the construction workers exceed the referents. Comparison of the congener profiles suggests that there are substantial differences between the construction workers and the general population samples. These differences, and the similarities of profiles among the construction workers strongly suggest that occupational contact with caulking material can be a major source of PCB exposure for construction workers.