Sample bias among women with retained DNA samples for future genetic studies.
Sample bias among women with retained DNA samples for future genetic studies.
复制标题
保留 DNA 样本用于未来基因研究的女性的样本偏差。
DOI：
10.1097/01.aog.0000241536.19539.14
复制
发表时间：
2006
影响因子：
7.2
通讯作者：
中科院分区：
文献类型：
--
作者：
Aagaard-Tillery,Kjersti;Sibai,Baha;Spong,CatherineY;Momirova,Valerija;WendelJr,George;Wenstrom,Katharine;Samuels,Philip;Cotroneo,Margaret;Moawad,Atef;Sorokin,Yoram;Miodovnik,Menachem;Meis,Paul;O'Sullivan,MaryJ;Conway,Deborah;
目的：评估同意将来使用生物标本进行基因研究的妇女是否反映了她们所衍生的更大的研究人群。方法：在一项多中心观察性研究中，妇女接受了关于其母体和胎儿DNA样本未来处置的询问，该研究最初旨在识别因子V莱顿突变携带者，并前瞻性地确定妊娠相关静脉血栓栓塞症和不良妊娠结局的估计发生率。对5,188名登记的女性中的5,003人进行了单因素和多因素分析。结果：在这5,003名女性中，20.1%的人希望她们的样本被丢弃，不能用于未来的遗传学研究。多因素分析显示，同意随后使用样本的女性不太可能是非洲裔美国人(优势比[OR]0.6，95%可信区间[CI]0.4-0.7)或西班牙裔(OR 0.4，95%CI 0.3-0.5)，而更有可能使用烟草(OR 1.2，95%CI 1.0-1.6)。结论：同意在样本库中使用样本的女性的基因样本可能不能代表指数研究队列。在随后的解释和推广中应考虑这一点。证据水平：IIIG同意在较大研究背景下使用的妇女遗传样本可能不能代表研究队列。
OBJECTIVE: To evaluate whether women who agree to future use of their biologic specimens for genetic studies reflect the larger study population from which they are derived.METHODS: Women were questioned as to the future disposition of their maternal and fetal DNA samples upon enrollment in a multicenter, observational study originally designed to identify factor V Leiden mutation carriers and prospectively ascertain the estimated rate of pregnancy-related venous thromboembolism and adverse pregnancy outcome. Univariate and multivariate analyses was carried out on the 5,003 of 5,188 enrolled women who indicated their desire regarding future disposition of their DNA samples.RESULTS: Among these 5,003 women, 20.1% desired that their samples be discarded and not available for future genetic studies. Multivariate analysis demonstrated that women who agreed to subsequent use of samples were less likely African-American (odds ratio [OR] 0.6, 95% confidence interval [CI] 0.4–0.7) or Hispanic (OR 0.4, 95% CI 0.3–0.5), and more likely to use tobacco (OR 1.2, 95% CI 1.0–1.6) than those who desired that their samples be discarded.CONCLUSION: Genetic samples from women agreeing to their use in a sample repository may not be representative of the index study cohort. This should be considered in their subsequent interpretation and generalizability.LEVEL OF EVIDENCE: IIIGenetic samples from women agreeing to their use within the context of larger studies may not be representative of the study cohort.
影响因子：
8
作者：
Arndt Hartmann;Hagen Blaszyk;Renee M. McGovern;J. Schroeder;Julie M. Cunningham;E. M. G. D. Vries;John S. Kovach;S. Sommer
通讯作者：
Arndt Hartmann;Hagen Blaszyk;Renee M. McGovern;J. Schroeder;Julie M. Cunningham;E. M. G. D. Vries;John S. Kovach;S. Sommer
DOI：
--
发表时间：
2000-10
期刊：
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
影响因子：
--
作者：
R. Fan;M. Wu;D. Miller;J. Wain;K. Kelsey;J. Wiencke;D. Christiani
通讯作者：
R. Fan;M. Wu;D. Miller;J. Wain;K. Kelsey;J. Wiencke;D. Christiani
影响因子：
29.4
作者：
T. Shepherd;D. Tolbert;J. Benedetti;J. Macdonald;G. Stemmermann;J. Wiest;G. Devoe;M. Miller;J. Wang;A. Noffsinger;C. Fenoglio-Preiser
通讯作者：
T. Shepherd;D. Tolbert;J. Benedetti;J. Macdonald;G. Stemmermann;J. Wiest;G. Devoe;M. Miller;J. Wang;A. Noffsinger;C. Fenoglio-Preiser