Short communication: adverse chronic effects of high-dose irradiation on proximal bronchus in patients treated for bronchogenic carcinoma.
Short communication: adverse chronic effects of high-dose irradiation on proximal bronchus in patients treated for bronchogenic carcinoma.
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简短的交流：高剂量照射对支气管癌患者近端支气管的慢性不良影响。
DOI：
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发表时间：
1993
影响因子：
2.6
通讯作者：
H. Niibe
中科院分区：
文献类型：
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作者：
K. Hayakawa;N. Mitsuhashi;Y. Saito;N. Nakajima;H. Niibe
5 名肺表皮样癌患者接受肺门区 80 Gy 小射野 40 次/8-11 周 (TDF123-129) 治疗，其中 4 名患者出现近端支气管明显狭窄，但肿瘤未进展，并在放疗后 1-3 年死于肺功能不全。这些结果应作为放射剂量升级的警告，并且治疗肺门病变的最佳剂量上限可能低于 80 Gy。
Of five patients with epidermoid carcinoma of the lung who were treated with small fields of 80 Gy in 40 fractions/8-11 weeks (TDF123-129) to the hilar region, four patients developed marked stenosis of the proximal bronchi without tumour progression and died of pulmonary insufficiency 1-3 years after radiotherapy. These results should serve as a warning against escalation of the radiation dose, and the upper optimal dose might prove to be less than 80 Gy for the treatment of pulmonary hilar lesions.