Movement induced modulation of afferent transmission to single neurons in the ventroposterior thalamus and somatosensory cortex in rat.
Movement induced modulation of afferent transmission to single neurons in the ventroposterior thalamus and somatosensory cortex in rat.
复制标题
运动诱导对大鼠腹后丘脑和体感皮层单个神经元的传入传输的调节。
DOI：
10.1007/bf02423500
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发表时间：
1990
影响因子：
2
通讯作者：
Chapin,JK
中科院分区：
文献类型：
--
作者：
Shin,HC;Chapin,JK
在休息和跑步行为期间，同时记录清醒大鼠的初级体感（SI）皮层和腹后外侧（VPL）丘脑的前爪区域的单个神经元。当小动物在定时跑步机上跑步时，通过长期植入前爪皮肤下的电极生成这些神经元对刺激的反应的刺激后直方图，测试体细胞感觉传递的运动依赖性变化。从爪子刺激后直方图中可以看出，诱发单位反应（EUR）可以分为短（4.5±0.1−10.9±0.2ms）和长（12.9±0.431.3±±0.9ms）潜伏期成分（分别为“SEURs”和“LEURs”）。测量这些反应期间的放电强度并将其标准化为相对于背景放电的百分比增加。与休息行为相比，跑步机运动抑制了丘脑以及皮质中的 SEUR 和 LEUR。然而，SEUR 在 SI 皮质 (-48.3 ± 2.7%) 中比在 VPL 丘脑 (-28.1 ± 6.7%) 中受到更强烈的抑制。相比之下，在 SI (-25.8 ± 8.6%) 和 VPL (-26.5 ± 11.1%) 中发现了类似的 LEUR 抑制程度。这些结果表明，在 SI 皮层中观察到的 LEUR 的抑制可能是由于皮层下回路的调节作用所致。另一方面，SEUR 的主要抑制可能发生在皮质内，一小部分发生在皮质下。因此，大鼠的 VPL 丘脑和 SI 皮质似乎不同地受到与运动相关的感觉传递调节。
Single neurons were simultaneously recorded in the forepaw areas of the primary somatosensory (SI) cortex and ventroposterolateral (VPL) thalamus of awake rats during rest and running behaviors. Movement dependent changes in somatic sensory transmission were tested by generating post-stimulus histograms of these neurons' responses to stimulation through electrodes chronically implanted under the skin of the forepaw, while the aminal ran on a timed treadmill. As viewed in post-paw-stimulus histograms, the evoked unit responses (EURs) could be differentiated into short (4.5 ± 0.1−10.9 ± 0.2 ms) and longer (12.9 ± 0.4 31.3 ± ± 0.9 ms) latency components (“SEURs” and “LEURs”, respectively). The magnitudes of firing during these responses were measured and normalized as percent increases over background firing. By comparison with resting behavior, treadmill movement suppressed both SEURs and LEURs in the thalamus, as well as the cortex. The SEURs, however, were much more strongly suppressed in the SI cortex (−48.3 ± 2.7%) than in the VPL thalamus (−28.1 ± 6.7%). By contrast, similar magnitudes of suppression of LEURs were found in the SI (−25.8 ± 8.6%) and VPL (−26.5 ± 11.1%). These results suggest that the suppression of LEURs observed in the SI cortex may result from modulatory actions on subcortical circuits. Major suppression of SEURs, on the other hand, may occur intracortically, with a minor component ocurring subcortically. Thus, VPL thalamus and SI cortex in the rat appear to be differentially subject to movement related modulation of sensory transmission.