Association of foot ulcer with tibial artery calcification is independent of peripheral occlusive disease in type 2 diabetes.
Association of foot ulcer with tibial artery calcification is independent of peripheral occlusive disease in type 2 diabetes.
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DOI：
10.1016/j.diabres.2012.12.022
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发表时间：
2013-03
影响因子：
5.1
通讯作者：
Stein, C. Michael
中科院分区：
文献类型：
--
作者：
Guzman, Raul J.;Bian, Aihua;Shintani, Ayumi;Stein, C. Michael
旨在确定 2 型糖尿病患者足部溃疡、动脉钙化和外周闭塞性疾病之间的关系。我们对 162 名 2 型糖尿病患者进行了一项横断面研究，他们通过平扫 CT 扫描评估了胫动脉钙化 (TAC)。通过血管造影评估外周动脉闭塞性疾病。就诊时记录足部状况，包括是否存在溃疡。使用多变量逻辑回归模型来评估足部溃疡、动脉钙化和外周动脉粥样硬化闭塞性疾病程度之间的关联。患有足部溃疡的患者 (n= 31) 更有可能年龄较大且有吸烟史。他们也更有可能有较高的 TAC 评分（中位 [IQR]：4324.6 [609.9, 11163.6] vs. 9.4 [0.0, 343.9]，P < 0.001）和更严重的外周动脉闭塞性疾病（闭塞指数 5.5 [4.8, 6.4] vs. 2.2 [1.0, 3.6]，P < 0.001。在多变量回归模型中，足部溃疡与 TAC 评分升高密切相关（优势比 [95% CI] = 2.76 [1.61, 4.75]，P = 0.0002），在调整 2 型糖尿病患者的动脉粥样硬化程度后，动脉钙化与糖尿病足部溃疡之间仍然存在密切相关性。
To determine the relationship between foot ulcers, arterial calcification, and peripheral occlusive disease in patients with type 2 diabetes. We performed a cross-sectional study on 162 patients with type 2 diabetes who underwent assessment of tibial artery calcification (TAC) by non-contrasted CT scan. Peripheral artery occlusive disease was assessed by angiography. Foot status including the presence or absence of ulcers was documented at presentation. A multivariable logistic regression model was used to evaluate the association between foot ulcers, arterial calcification, and the extent of peripheral atherosclerotic occlusive disease. Patients with foot ulcers (n= 31) were more likely to be older and have a history of tobacco use. They were also more likely to have higher TAC scores (median [IQR]: 4324.6 [609.9, 11163.6] vs. 9.4 [0.0, 343.9], P < 0.001) and more advanced peripheral artery occlusive disease (occlusion index 5.5 [4.8, 6.4] vs. 2.2 [1.0, 3.6], P < 0.001. Foot ulcer was strongly associated with elevated TAC scores in a multivariable regression model (Odds ratio [95% CI] =2.76 [1.61, 4.75], P=0.0002). There is a strong association between arterial calcification and diabetic foot ulcers that persists after adjusting for the extent of atherosclerosis in patients with type 2 diabetes.
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DOI：
10.1053/ejvs.1999.0825
发表时间：
1999-06-01
影响因子：
5.7
作者：
Biancari, F;Albäck, A;Lepäntalo, M
通讯作者：
Lepäntalo, M
影响因子：
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作者：
CORBIN, DOC;YOUNG, RJ;CLARKE, BF
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CLARKE, BF
影响因子：
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作者：
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JEFFCOATE, WJ
影响因子：
2.8
作者：
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通讯作者：
Golledge, Jonathan
影响因子：
4.3
作者：
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