Incorporation of casein phosphopepticle-amorphous calcium phosphate into a glass-ionomer cement
Incorporation of casein phosphopepticle-amorphous calcium phosphate into a glass-ionomer cement
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DOI：
10.1177/154405910308201113
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发表时间：
2003-11-01
影响因子：
7.6
通讯作者：
Reynolds, EC
中科院分区：
文献类型：
--
作者：
Mazzaoui, SA;Burrow, MF;Reynolds, EC
酪蛋白磷酸肽-无定形磷酸钙（CPP-ACP）纳米复合物已被证明可以防止脱矿作用，并促进动物和原位龋齿模型中釉质亚表面病变的再矿化。本研究的目的是确定将CPP-ACP掺入自固化玻璃离子水门汀（GIC）中的效果。将1.56%w/w CPP-ACP掺入GIC中显著增加了微拉伸结合强度（33%）和压缩强度（23%），并显著增强了钙，磷酸盐和氟离子在中性和酸性pH值下的释放。MALDI质谱法还显示了从CPP-ACP纳米复合物中释放的酪蛋白磷酸肽。在体外酸挑战过程中，从含有CPP-ACP的GIC中释放CPP-ACP和氟化物与增强对邻近牙本质的保护相关。
Casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) nanocomplexes have been shown to prevent demineralization and promote remineralization of enamel subsurface lesions in animal and in situ caries models. The aim of this study was to determine the effect of incorporating CPP-ACP into a self-cured glass-ionomer cement (GIC). Incorporation of 1.56% w/w CPP-ACP into the GIC significantly increased microtensile bond strength (33%) and compressive strength (23%) and significantly enhanced the release of calcium, phosphate, and fluoride ions at neutral and acidic pH. MALDI mass spectrometry also showed casein phosphopeptides from the CPP-ACP nanocomplexes to be released. The release of CPP-ACP and fluoride from the CPP-ACP-containing GIC was associated with enhanced protection of the adjacent dentin during acid challenge in vitro.