Motoric cognitive risk syndrome and risk of mortality in older adults
Motoric cognitive risk syndrome and risk of mortality in older adults
复制标题
DOI：
10.1016/j.jalz.2015.08.167
复制
发表时间：
2016-05-01
影响因子：
14
通讯作者：
Verghese, Joe
中科院分区：
文献类型：
--
作者：
Ayers, Emmeline;Verghese, Joe
引言：认知障碍与死亡率增加有关。我们研究了运动性认知风险（MCR）综合征（一种以缓慢步态和认知障碍为特征的痴呆前期综合征）与生存率之间的关系。方法：在美国和欧洲的三项已建立的队列研究中，共筛选了11，867名年龄>65岁的非痴呆受试者进行MCR筛查。MCR的死亡风险用考克斯和logistic回归模型进行评估。结果：基线时，836例（7.0%）受试者有MCR。在平均28个月的随访中，1603名参与者死亡（前两年758人）。MCR与总体死亡率（校正风险比，1.69; 95%置信区间[CI]，1.46-1.96）和2年死亡率（校正比值比，1.89; 95% CI，1.50-2.38）增加相关。在考虑了既定的死亡风险因素以及基线步态速度和记忆表现后，这种关联仍然存在。老年人应进行MCR筛查，以确定痴呆和死亡的风险个体。(C)2015年阿尔茨海默氏症协会。爱思唯尔公司出版All rights reserved.
Introduction: Cognitive impairment is associated with increased mortality. We examined the association between motoric cognitive risk (MCR) syndrome, a predementia syndrome characterized by slow gait and cognitive complaints, and survival.Methods: A total of 11,867 nondemented participants aged >65 years from three established cohort studies in the United States and Europe were screened for MCR. Mortality risk of MCR was assessed with Cox and logistic regression models.Results: At baseline, 836 (7.0%) participants had MCR. Over a median follow-up of 28 months, 1603 participants died (758 in first 2 years). MCR was associated with increased mortality overall (adjusted hazard ratio, 1.69; 95% confidence interval [CI], 1.46-1.96) and 2-year mortality (adjusted odds ratio, 1.89; 95% CI, 1.50-2.38). The association remained after accounting for established mortality risk factors as well as baseline gait speed and memory performance.Discussion: MCR is associated with increased mortality. Older adults should be screened for MCR to identify at-risk individuals for dementia and death. (C) 2015 Alzheimer's Association. Published by Elsevier Inc. All rights reserved.