Hepatoprotection by L-cysteine-glutathione mixed disulfide, a sulfhydryl-modified prodrug of glutathione
Hepatoprotection by L-cysteine-glutathione mixed disulfide, a sulfhydryl-modified prodrug of glutathione
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DOI：
10.1002/jbt.10069
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发表时间：
2003-01-01
影响因子：
3.6
通讯作者：
Nagasawa, HT
中科院分区：
文献类型：
--
作者：
Berkeley, LI;Cohen, JF;Nagasawa, HT
L-半胱氨酸-谷胱甘肽二硫化物是一种普遍存在于哺乳动物细胞中的物质，已被证明在保护小鼠免受对乙酰氨基酚诱导的肝毒性方面非常有效。由于相应的D-半胱氨酸-谷胱甘肽二硫化物在这方面是完全无效的，因此假设直接向细胞提供谷胱甘肽的酶机制。(C)2003 Wiley Periodicals，Inc.
L-Cysteine-glutathione disulfide, a ubiquitous substance present in mammalian cells, was shown to be highly effective in protecting mice against acetaminophen-induced hepatotoxicity. Since the corresponding D-cysteine-glutathione disulfide was totally ineffective in this regard, an enzymatic mechanism that provides glutathione directly to cells is postulated. (C) 2003 Wiley Periodicals, Inc.