Effect of gelatin on dimensional stability of silk fibroin hydrogel structures fabricated by digital light processing 3D printing
Effect of gelatin on dimensional stability of silk fibroin hydrogel structures fabricated by digital light processing 3D printing
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DOI：
10.1016/j.jiec.2020.03.034
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发表时间：
2020-09-25
影响因子：
6.1
通讯作者：
Hyun, Jinho
中科院分区：
文献类型：
--
作者：
Lee, Hyunji;Shin, Donghyeok;Hyun, Jinho
这项工作描述了用于数字光处理3D打印的丝素（SF）基油墨材料的开发。核黄素在可见光照射下启动SF分子的交联，通过二酪氨酸键形成SF水凝胶。在37摄氏度的磷酸盐缓冲盐水溶液中，快速形成的-片结构会导致SF水凝胶收缩。在SF油墨中加入明胶可以有效地防止SF水凝胶的收缩。随着复合油墨中明胶含量的增加，β -片结构的密度降低，3D SF/明胶水凝胶的结构变形受到抑制。打印性是制造3D SF/明胶复合水凝胶结构的关键。为了评价打印性能，将3D打印形成的水凝胶的实际宽度与设计宽度进行了比较。SF的3D打印是通过垂直方式照射一系列不同形状或大小的特征来完成的。(C) 2020韩国工业与工程化学学会。Elsevier B.V.版权所有。
This work describes development of a silk fibroin (SF)-based ink material for digital light processing 3D printing. Riboflavin initiates the crosslinking of SF molecules under irradiation with visible light to form an SF hydrogel through dityrosine bonding. Rapid formation of a beta-sheet structure induces shrinkage of SF hydrogels in phosphate-buffered saline solution at 37 degrees C. Such shrinkage of SF hydrogel is effectively prevented by addition of gelatin to SF ink. As the ratio of gelatin in the composite ink is increased, the density of beta-sheet structures is reduced, and structural deformation of the 3D SF/gelatin hydrogel is inhibited. Printability is critical in fabrication of 3D SF/gelatin composite hydrogel structures. For evaluation of printing performance, the actual width of the hydrogel formed by 3D printing is compared with the designed width. The 3D printing of SF is performed by irradiating a series of features with different shapes or sizes in a vertical manner. (C) 2020 The Korean Society of Industrial and Engineering Chemistry. Published by Elsevier B.V. All rights reserved.