Metabolic syndrome in polycystic ovary syndrome (PCOS): lower prevalence in southern Italy than in the USA and the influence of criteria for the diagnosis of PCOS
Metabolic syndrome in polycystic ovary syndrome (PCOS): lower prevalence in southern Italy than in the USA and the influence of criteria for the diagnosis of PCOS
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DOI：
10.1530/eje.1.02058
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发表时间：
2006-01-01
影响因子：
5.8
通讯作者：
Lobo, RA
中科院分区：
文献类型：
--
作者：
Carmina, E;Napoli, N;Lobo, RA
目的：代谢综合征（MBS）是多囊卵巢综合征（PCOS）的常见病、多发病。在美国，使用成人治疗组III（ATP-III）标准，PCOS中MBS的患病率据报道高达43-46%。由于饮食、生活方式和遗传因素的差异。我们推测NIBS在意大利妇女中的患病率可能不高。本研究旨在确定MBS的患病率在意大利妇女使用ATP-III和世界卫生组织（WHO）的标准，并确定是否患病率的方式，其中PCOS是diagnosed.Design的影响：评估MBS的患病率在282名妇女与PCOS。年龄18-40岁。住在西西里西部85名年龄和体重相匹配的正常妇女作为controls.Methods：患者分为慢性无排卵和高雄激素血症（经典PCOS; n = 225）和高雄激素血症和多囊卵巢，但谁是排卵（排卵PCOS：它= 57）。进行75 g口服葡萄糖耐量试验。与血脂测定一样，通过定量胰岛素敏感性检查指数（QUICK）评估胰岛素抵抗。我们使用ATP-Ⅲ和WHO标准诊断MBS。结果：使用ATP-Ⅲ标准，MBS的患病率为8.2%，使用WHO标准，这是16%的意大利PCOS妇女。在对照组中，使用两种方法的患病率为2.4%。在典型PCOS患者中，MBS（ATP-III为8.9%，WHO为17.3%）高于排卵型PCOS（分别为5%和10.6%）。体重显着修改患病率。结论：MBS是实质上较高的PCOS妇女比一般人群。在那些按经典标准诊断的妇女中，患病率较高。然而.在意大利，多囊卵巢综合征中MBS的患病率似乎比美国低得多。
Objective: Metabolic syndrome (MBS) is a common disorder and is thought to be extremely prevalent in polycystic ovary syndrome (PCOS). In the USA the prevalence of MBS in PCOS has been reported to be as high as 43-46% using Adult Treatment Panel III (ATP-III) criteria. Because of differences in diet, lifestyle and genetic factors. we postulated that the prevalence of NIBS might not be as high in Italian women. This study sought to determine the prevalence of MBS in Italian women using both the ATP-III and the World Health Organization (WHO) criteria and to determine whether the prevalence is influenced by the way in which PCOS is diagnosed.Design: Assessment of the prevalence of MBS in 282 women with PCOS. aged 18-40 years. living in western Sicily. Eighty-five age- and weight-matched normal women served as controls.Methods: Patients were divided into those with chronic anovulation and hyperandrogenism (classic PCOS; n = 225) and others with hyperandrogenism and polycystic ovaries but who were ovulatory (ovulatory PCOS: it = 57). A 75 g oral glucose tolerance test was carried out. as were lipid determinations; insulin resistance was assessed by the Quantitative Insulin-Sensitivity Check Index (QUICK[). We used ATP-III and WHO criteria to diagnose MBS.Results: Using ATP-III criteria, the prevalence of MBS was 8.2% and using WHO criteria it was 16% in Italian women with PCOS. In controls, the prevalence was 2.4% using both methods. In classic PCOS patients, MBS was higher (8.9% by ATP-III, 17.3% by WHO) than in ovulatory PCOS (5% and 10.6% respectively). Body weight significantly modified prevalence rates.Conclusion: MBS is substantially higher in women with PCOS than in the general population. and the prevalence is higher in those women diagnosed by classic criteria. However. the prevalence of MBS in PCOS appears to be much lower in Italy than in the USA.