Overview for the histone codes for DNA repair.
Overview for the histone codes for DNA repair.
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DOI：
10.1016/b978-0-12-387665-2.00008-0
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发表时间：
2012
影响因子：
--
通讯作者：
Hromas, Robert
中科院分区：
文献类型：
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作者：
Williamson, Elizabeth A.;Wray, Justin W.;Bansal, Pranshu;Hromas, Robert
由于细胞内代谢、复制和暴露于基因毒性物质（如电离辐射和化疗）等多种因素，DNA损伤不断发生。如果不进行修复，这种损伤可能导致细胞基因组物质的变化或突变。细胞可以利用许多不同的途径来修复这些DNA断裂。然而，了解DNA损伤如何向各种DNA途径发出信号是人们最感兴趣的。当DNA损伤发生在染色质内时，我们假设组蛋白的修饰对于发出DNA损伤位置的信号，将DNA修复蛋白招募到损伤部位，并创建一个开放的结构，使修复蛋白可以进入损伤部位是重要的。我们讨论了发生在组蛋白上的修饰，以及它们与已经发生的损伤类型以及激活的DNA修复途径相关的方式。
DNA damage occurs continuously as a result of various factors—intracellular metabolism, replication, and exposure to genotoxic agents, such as ionizing radiation and chemotherapy. If left unrepaired, this damage could result in changes or mutations within the cell genomic material. There are a number of different pathways that the cell can utilize to repair these DNA breaks. However, it is of utmost interest to know how the DNA damage is signaled to the various DNA pathways. As DNA damage occurs within the chromatin, we postulate that modifications of histones are important for signaling the position of DNA damage, recruiting the DNA repair proteins to the site of damage, and creating an open structure such that the repair proteins can access the site of damage. We discuss the modifications that occur on the histones and the manner in which they relate to the type of damage that has occurred as well as the DNA repair pathways that are activated.