Interleukin 18 participates in the early inflammatory response and bacterial clearance during pneumonia caused by nontypeable Haemophilus influenzae
Interleukin 18 participates in the early inflammatory response and bacterial clearance during pneumonia caused by nontypeable Haemophilus influenzae
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DOI：
10.1128/iai.00287-07
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发表时间：
2007-10-01
影响因子：
3.1
通讯作者：
van der Poll, Tom
中科院分区：
文献类型：
--
作者：
Wieland, Catharina W.;Florquin, Sandrine;van der Poll, Tom
不可分型流感嗜血杆菌（NTHi）是一种常见的革兰氏阴性呼吸道病原体。为了确定促炎细胞因子白细胞介素18 （IL-18）在NTHi肺炎中的作用，将正常野生型（WT）和IL-18敲除（KO）小鼠鼻内感染NTHi IL-18， KO小鼠表现出呼吸道NTHi清除的延迟，导致感染后24小时肺部细菌负荷增加20倍，在此之前，通过细胞因子和趋化因子诱导和组织病理学检测发现肺部先天免疫反应强烈减弱。这些数据确定IL-18是NTHi肺炎期间充分的先天免疫反应的一部分。
Nontypeable Haemophilus influenzae (NTHi) is a common gram-negative respiratory pathogen. To determine the role of the proinflammatory cytokine interleukin 18 (IL-18) during NTHi pneumonia, normal wild-type (WT) and IL-18 knockout (KO) mice were intranasally infected with NTHi IL-18 KO mice displayed a delayed clearance of NTHi from the respiratory tract, resulting in > 20-fold higher bacterial loads in their lungs at 24 h after infection, preceded by a strongly attenuated pulmonary innate immune response as determined by cytokine and chemokine induction and histopathology. These data identify IL-18 as part of an adequate innate immune response during NTHi pneumonia.