SINDBIS VIRUS PROTEINS NSP1 AND NSP2 CONTAIN HOMOLOGY TO NONSTRUCTURAL PROTEINS FROM SEVERAL RNA PLANT-VIRUSES
SINDBIS VIRUS PROTEINS NSP1 AND NSP2 CONTAIN HOMOLOGY TO NONSTRUCTURAL PROTEINS FROM SEVERAL RNA PLANT-VIRUSES
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DOI：
10.1128/jvi.53.2.536-542.1985
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发表时间：
1985-01-01
影响因子：
5.4
通讯作者：
ZIMMERN, D
中科院分区：
文献类型：
--
作者：
AHLQUIST, P;STRAUSS, EG;ZIMMERN, D
烟草花叶病毒（TMV）与苜蓿花叶病毒（AIMV）和雀麦花叶病毒（BMV）的遗传结构有很大的不同，但它们的非结构蛋白都有3个同源结构域。AIMV和BMV 2a蛋白共有的一个这样的结构域，以及TMV p183的通读部分，也与辛德毕斯病毒的通读蛋白nsP4同源。另外两个结构域在AIMV和BMV 1a蛋白和TMV p126之间是保守的。这些结构域分别与辛德毕斯蛋白nsP1和nsP2的部分具有同源性。这些结果加强了这样的观点，即4种病毒在其复制策略中具有相似的机制，并且可能在进化上相关。这些结果还表明，AIMV 1a，BVM 1a和TMV p126蛋白是多功能的，或者Sindbis蛋白nsP1和nsP2作为单一复合物中的亚基一起起作用。
Although the genetic organization of tobacco mosaic virus (TMV) differs considerably from that of the tripartite viruses (alfalfa mosaic virus [AIMV] and brome mosaic virus [BMV]), all of these RNA plant viruses share 3 domains of homology among their nonstructural proteins. One such domain, common to the AIMV and BMV 2a proteins, and the readthrough portion of TMV p183, is also homologous to the readthrough protein nsP4 of Sindbis virus. Two more domains are conserved among the AIMV and BMV 1a proteins and TMV p126. These domains have homology with portions of the Sindbis proteins nsP1 and nsP2, respectively. These results strengthen the view that the 4 viruses share mechanistic similarities in their replication strategies and may be evolutionarily related. These results also suggest that either the AIMV 1a, BVM 1a and TMV p126 proteins are multifunctional or Sindbis proteins nsP1 and nsP2 function together as subunits in a single complex.