Type I diabetes mellitus. A chronic autoimmune disease.
Type I diabetes mellitus. A chronic autoimmune disease.
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DOI：
10.1056/nejm198605223142106
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发表时间：
1986-05
期刊：
影响因子：
--
通讯作者：
G. Eisenbarth
中科院分区：
文献类型：
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作者：
G. Eisenbarth
在过去的十年中，关于I型糖尿病发病机制的大量信息已经变得可用。已经发现并表征了该疾病的两种自发动物模型（Biobreeding大鼠和非肥胖糖尿病小鼠）;已经认识到人类、小鼠和大鼠I型糖尿病中主要组织相容性复合体中一个或多个基因的重要性;并且已经确定了选定的胰岛细胞抗体测定的预后重要性。糖尿病之前的T细胞异常已经被发现。有证据表明，第一时相胰岛素分泌的进行性丧失先于糖尿病和免疫。. .
DURING the past decade a wealth of information concerning the pathogenesis of Type I diabetes has become available. Two spontaneous animal models of the disease have been discovered and characterized (the Biobreeding rat and the non-obese diabetic mouse); the importance of a gene or genes in the major histocompatibility complex in Type I diabetes of human beings, of mice, and of rats has been appreciated; and the prognostic importance of selected assays for islet-cell antibodies has been defined. T-cell abnormalities that precede diabetes have been discovered. Evidence has suggested that progressive loss of first-phase insulin secretion precedes diabetes, and immunologic . . .