Angiotensin Tachyphylaxis and its Reversal
Angiotensin Tachyphylaxis and its Reversal
复制标题
血管紧张素快速耐受及其逆转
DOI：
10.1161/01.res.19.2.247
复制
发表时间：
1966
影响因子：
20.1
通讯作者：
R. Turker
中科院分区：
文献类型：
--
作者：
P. Khairallah;Irvine H. Page;F. Bumpus;R. Turker
在猫、狗、羊和大鼠的螺旋切开的动脉条上，以及在兔和猫的静脉条上，已经证明了血管紧张素及其类似物的快速药理作用。兔动脉和豚鼠动脉似乎没有发生过速。血管紧张素C端的游离羧基是与受体结合和发生快速反应所必需的。快速反应似乎代表了受体位置的饱和。它可以被富含血管紧张素酶A的血浆组分逆转，可能是通过直接从结合状态代谢血管紧张素的N端部分。Dowex 50也可以逆转它，可能是通过物理吸附和更强的血管紧张素结合。血管紧张素酶A不代谢β天冬氨酸氨基-血管紧张素，也不逆转对这种多肽的快速反应。提出了一种可能的多肽与受体结合的方案。
Tachyphylaxis to angiotensin and some analogues has been demonstrated on spirally cut arterial strips from cat, dog, sheep and rat, and on venous strips from rabbit and cat. Rabbit and guinea pig arteries do not appear to become tachyphylactic. A free C-terminal carboxyl group of angiotensin is necessary for binding with receptor sites and development of tachyphylaxis. Tachyphylaxis seems to represent saturation of receptor sites. It can be reversed by plasma fractions rich in angiotensinase A, possibly by metabolizing the N-terminal part of angiotensin directly from the bound state. Dowex 50 can also reverse it, probably by physical adsorption and stronger binding of angiotensin. Angiotensinase A does not metabolize βaspartyl1-angiotensin and does not reverse tachyphylaxis to this peptide. A possible scheme of interaction between peptide and receptor site is presented.