End-tidal carbon dioxide monitoring during cardiopulmonary resuscitation.
End-tidal carbon dioxide monitoring during cardiopulmonary resuscitation.
复制标题
心肺复苏期间呼气末二氧化碳监测。
DOI：
10.1001/jama.1987.03390040128031
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发表时间：
1987
期刊：
影响因子：
--
通讯作者：
E. Johnson
中科院分区：
文献类型：
--
作者：
A. R. Garnett;J. Ornato;E. R. Gonzalez;E. Johnson
在动物模型中，呼气末二氧化碳(CO2)浓度与心肺复苏(CPR)期间和之后的心输出量相关。我们在23名患者的心脏复苏期间连续监测呼气末二氧化碳浓度，同时使用计算机控制的CPR Thumper保持恒定的通气量。这份报告集中在23名在监测期间经历自主循环恢复(ROSC)的患者中的10名。无ROSC患者的呼气末CO2值(1.8%+/-0.9%)和ROSC患者行ROSC前患者的呼气末CO2值(1.7%+/-0.6%)无显著差异。所有患有ROSC的患者的呼气末二氧化碳浓度立即升高，从1.7%+/-0.6%上升到4.6%+/-1.4%，然后逐渐恢复到新的基线(3.1%+/-0.9%)。呼气末二氧化碳值的变化通常是ROSC发生的第一个临床指标。我们的发现表明，呼气末二氧化碳监测可能提供临床上有用的信息，可用于指导心肺复苏期间的治疗。
The end-tidal carbon dioxide (CO2) concentration has been found to correlate with cardiac output during and after cardiopulmonary resuscitation (CPR) in animal models. We monitored end-tidal CO2 values continuously during cardiac resuscitation in 23 humans while ventilation was held constant with a computer-controlled CPR Thumper. This report focuses on ten of the 23 patients who experienced return of spontaneous circulation (ROSC) during monitoring. There was no significant difference in the end-tidal CO2 value of patients without ROSC (1.8% +/- 0.9%) and the end-tidal CO2 value of patients before ROSC in patients who had ROSC (1.7% +/- 0.6%). The end-tidal CO2 concentration increased immediately in all patients who had ROSC, from 1.7% +/- 0.6% to 4.6% +/- 1.4%, then gradually returned to a new baseline (3.1% +/- 0.9%). Change in the end-tidal CO2 value was often the first clinical indicator that ROSC had occurred. Our findings suggest that end-tidal CO2 monitoring may provide clinically useful information that can be used to guide therapy during CPR.