Pd-Catalyzed Regioselective 1,2-Difunctionalization of Vinylarenes with Alkenyl Triflates and Aryl Boronic Acids at Ambient Temperature
Pd-Catalyzed Regioselective 1,2-Difunctionalization of Vinylarenes with Alkenyl Triflates and Aryl Boronic Acids at Ambient Temperature
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DOI：
10.1021/acs.orglett.7b01036
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发表时间：
2017-05-19
期刊：
影响因子：
5.2
通讯作者：
Song, Qiuling
中科院分区：
文献类型：
--
作者：
Kuang, Zhijie;Yang, Kai;Song, Qiuling
本发明公开了一种钯催化的乙烯基芳烃的高区域选择性11，2-双官能化反应，其中多取代烯烃在环境温度下有效和方便地构建，具有良好的相容性和宽的底物范围。值得注意的是，四元碳中心可以很容易地从1，1-二取代的苯乙烯中建立起来，这在以前的方法中是很大的挑战。
A Pd-catalyted highly regioselective11,2-difunctionalization of vinylarenes is disclosed in which multisubstituted olefins are efficiently arid conveniently constructed under ambient temperature with good compatibility and a broad substrate scope. Notably, a quarternary carbon center could be readily built up from 1,1-disubstituted styrenes, which are big challenges in the previous methods.