Interactions Between MAOA Genotype and Receipt of Public Assistance: Predicting Change in Depressive Symptoms and Body Mass Index.
Interactions Between MAOA Genotype and Receipt of Public Assistance: Predicting Change in Depressive Symptoms and Body Mass Index.
复制标题
MAOA 基因型与接受公共援助之间的相互作用：预测抑郁症状和体重指数的变化。
DOI：
10.1111/j.1532-7795.2010.00694.x
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发表时间：
2011
期刊：
影响因子：
--
通讯作者：
Hart,Daniel
中科院分区：
文献类型：
--
作者：
Marmorstein,NaomiR;Hart,Daniel
对应激的反应部分取决于单胺系统（MAOA）的遗传影响调节。我们研究了压力源（接受公共援助）和基因调节MAOA在预测青少年抑郁症状和体重指数（BMI）变化中的相互作用。参与者来自国家青少年健康纵向研究（Add Health）遗传信息子样本。我们关注男性是因为男性只有一个MAOA等位基因。采用生长曲线分析方法，评估公共援助、MAOA等位基因及其交互作用与抑郁症状和BMI的截距和斜率之间的关系。结果表明，在男性中，MAOA等位基因类型与接受公共援助在预测从青春期早期到成年早期的抑郁症状和BMI的变化率方面相互作用。家庭接受公共援助的短MAOA等位基因的男性倾向于经历抑郁症状和BMI的增加。了解压力，生理和发展之间的关系的研究结果的影响进行了讨论。
Response to stress is determined in part by genetically influenced regulation of the monoamine system (MAOA). We examined the interaction of a stressor (receipt of public assistance) and a gene regulating MAOA in the prediction of change in adolescent depressive symptoms and body mass index (BMI). Participants were drawn from the National Longitudinal Study on Adolescent Health (Add Health) genetically informative subsample. We focused on males due to the fact that males only have one MAOA allele. Growth curve analyses were conducted to assess the associations between public assistance, MAOA allele, and their interaction and the intercept and slope of depressive symptoms and BMI. The results indicated that among males, MAOA allele type interacted with receipt of public assistance in the prediction of rate of change in both depressive symptoms and BMI from early adolescence through early adulthood. Males with the short MAOA allele whose families received public assistance tended to experience increased growth in depressive symptoms and BMI. Implications of the findings for understanding the relations among stress, physiology, and development are discussed.