Household physical activity and cancer risk: a systematic review and dose-response meta-analysis of epidemiological studies.
Household physical activity and cancer risk: a systematic review and dose-response meta-analysis of epidemiological studies.
复制标题
家庭体力活动和癌症风险：流行病学研究的系统回顾和剂量反应荟萃分析
DOI：
10.1038/srep14901
复制
发表时间：
2015-10-07
影响因子：
4.6
通讯作者：
Nie S
中科院分区：
文献类型：
--
作者：
Shi Y;Li T;Wang Y;Zhou L;Qin Q;Yin J;Wei S;Liu L;Nie S
在过去的流行病学研究中，我们进行了荟萃分析，据报道家庭体育活动和癌症风险数量，尤其是在剂量响应方式，embase，Web，据报道了家庭体育活动与癌症风险之间的有争议的结果搜索了科学和Cochrane图书馆的队列或病例对照研究，该研究检查了家庭体育锻炼与进行了癌症风险。 30个研究包括41个比较符合纳入标准。最低的家庭活动（RR = 0.84，95％CI = 0.76–0.93）。每周额外的10小时小时，每1小时每周增加了0.99（95％CI = 0.98–0.99）。家庭体育活动与剂量反应效应中癌症风险降低有关。
Controversial results of the association between household physical activity and cancer risk were reported among previous epidemiological studies. We conducted a meta-analysis to investigate the relationship of household physical activity and cancer risk quantitatively, especially in dose-response manner. PubMed, Embase, Web of science and the Cochrane Library were searched for cohort or case-control studies that examined the association between household physical activity and cancer risks. Random–effect models were conducted to estimate the summary relative risks (RRs), nonlinear or linear dose–response meta-analyses were performed to estimate the trend from the correlated log RR estimates across levels of household physical activity quantitatively. Totally, 30 studies including 41 comparisons met the inclusion criteria. Total cancer risks were reduced 16% among the people with highest household physical activity compared to those with lowest household physical activity (RR = 0.84, 95% CI = 0.76–0.93). The dose-response analyses indicated an inverse linear association between household physical activity and cancer risk. The relative risk was 0.98 (95% CI = 0.97–1.00) for per additional 10 MET-hours/week and it was 0.99 (95% CI = 0.98–0.99) for per 1 hour/week increase. These findings provide quantitative data supporting household physical activity is associated with decreased cancer risk in dose-response effect.