Localized pemphigus exacerbation associated with underlying breast cancer.
Localized pemphigus exacerbation associated with underlying breast cancer.
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DOI：
10.1016/j.jdcr.2020.10.018
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发表时间：
2020-12
影响因子：
--
通讯作者：
Antiga E
中科院分区：
文献类型：
--
作者：
Maglie R;Montefusco F;Senatore S;D'Erme AM;Bagnoni G;Antiga E
恶性肿瘤可以诱发或加重天疱疮。副肿瘤性天疱疮（PNP）是一种罕见的天疱疮变体，也可能发生在患有基础恶性肿瘤的患者中。与包括PV和落叶型天疱疮在内的经典天疱疮变体不同，PNP的特征在于独特的临床和免疫病理学发现，包括严重的粘膜炎、内部并发症（如闭塞性细支气管炎）以及除Dsg 3和Dsg 1外的其他角质形成细胞抗原抗体。5，6虽然恶性肿瘤诱发或加重的天疱疮在切除肿瘤后通常会改善甚至消退，但PNP本质上会表现出更严重且可能危及生命的临床过程。因此，在这些实体之间进行鉴别诊断至关重要。7
DiscussionMalignancies can either induce or exacerbate pemphigus. Paraneoplastic pemphigus (PNP) is a rare pemphigus variant that also potentially occurs in patients with underlying malignancies. Unlike classical pemphigus variants, including PV and pemphigus foliaceus, PNP is characterized by distinct clinical and immunopathologic findings, including severe mucositis, internal complications such as bronchiolitis obliterans, and antibodies against other keratinocyte antigens in addition to Dsg3 and Dsg1. 5, 6 While malignancy-induced or-exacerbated pemphigus often ameliorates, or even resolves, following the removal of the tumor, PNP intrinsically runs a more severe and possibly life-threatening clinical course. Hence, making a differential diagnosis between these entities is crucial. 7