Stroop performance in major depression: Selective attention impairment or psychomotor slowness?
Stroop performance in major depression: Selective attention impairment or psychomotor slowness?
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DOI：
10.1016/j.jad.2009.08.009
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发表时间：
2010-04-01
影响因子：
6.6
通讯作者：
Amital, Daniela
中科院分区：
文献类型：
--
作者：
Kertzman, Semion;Reznik, Ilya;Amital, Daniela
背景：大量神经心理学研究报道了重度抑郁障碍(MOD)患者的Stroop表现受损。方法：本研究试图确定与未治疗的MDD门诊患者(n=75)和健康受试者(n=83)的这种损害相关的可能的神经心理学机制。检查时间、手指敲击时间、简单反应时间和选择反应时间分别作为感知、运动、精神运动速度和反应选择的指标。结果：MOD患者在中性和一致条件下的成绩显著低于正常对照组，但在不一致条件下无显著差异。为了确定Stroop性能的预测因素，进行了线性分层回归分析。年龄、运动和精神运动速度是Stroop成绩反应时间和准确性的预测因子。在三种Stroop条件下，MDD患者的反应时间与错误次数显著相关，而健康对照组只有在不一致的情况下才有这种相关性。限制：虽然我们的分析中包括了教育作为协变量，这表明观察到的影响不能归因于教育程度的差异，但有必要对教育匹配的样本进行进一步的检验。结论：我们的研究表明，Stroop任务绩效同时受到年龄和MDD的影响。在MDD门诊患者中，Stroop表现的损害可以通过精神运动迟缓和警觉水平来预测，但不能通过选择性注意本身的损害来预测。(C)2009爱思唯尔B.V.保留所有权利。
Background: Numerous neuropsychological studies reported impaired Stroop performance in major depressive disorder (MOD) patients.Methods: The present study attempted to identify possible neuropsychological mechanisms involved in this impairment in untreated MDD outpatients (n = 75) as compared to healthy subjects (n = 83). Inspection Time, Finger Tapping, Simple and Choice Reaction Time were considered as measures of perceptual, motor, psychomotor speed, and response selection, respectively.Results: MOD patients performed significantly slower than healthy controls in the neutral and the congruent conditions, but not in the incongruent ones. In order to identify predictors of Stroop performance, linear hierarchical regressions analyses were performed. Age, motor and psychomotor speed were predictors of response time and accuracy on Stroop performance. Significant correlations between response time and the number of errors in all three Stroop conditions were found in MDD patients, while such a correlation was obtained in the healthy controls only in the incongruent condition.Limitations: Although education was included as a covariate in our analyses, suggesting that the observed effects could not be ascribed to education differences, further testing with education-matched samples is warranted.Conclusions: Our study shows that the Stroop task performance is affected by both aging and MDD. Impairment in the Stroop performance can be predicted by psychomotor slowness and by vigilance level in MDD outpatients, but not by impairment of selective attention per se. (C) 2009 Elsevier B.V. All rights reserved.