Using electrodermal activity to validate multilevel pain stimulation in healthy volunteers evoked by thermal grills
Using electrodermal activity to validate multilevel pain stimulation in healthy volunteers evoked by thermal grills
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DOI：
10.1152/ajpregu.00102.2020
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发表时间：
2020-09-01
影响因子：
2.8
通讯作者：
Chon, Ki H.
中科院分区：
文献类型：
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作者：
Posada-Quintero, Hugo F.;Kong, Youngsun;Chon, Ki H.
我们已经测试了热烤架的可行性，这是一种无害的诱发疼痛的方法。热格栅由设置在冷或暖温度下的交错管组成，当冷和暖刺激共同呈现时，在大脑中产生痛苦的“错觉”（不会造成组织损伤）。客观疼痛评估研究的进展是有限的，因为黄金标准，自我报告的疼痛量表，是高度主观的，只适用于警觉和合作的患者。然而，疼痛研究的主要困难是对参与者造成的潜在伤害。我们招募了23名受试者，我们诱导电脉冲和热格栅（TG）刺激。TG有效地诱导了三种不同程度的疼痛，如受试者在每次刺激后提供的视觉模拟量表（VAS）所证明的。此外，基于皮肤电活动的客观生理测量显示，随着刺激水平的增加，水平显著增加。我们发现VAS与TG刺激水平高度相关。TG刺激安全地引起疼痛水平高达9/10。TG刺激允许将疼痛的研究扩展到其他刺激有害的疼痛范围。
We have tested the feasibility of thermal grills, a harmless method to induce pain. The thermal grills consist of interlaced tubes that are set at cool or warm temperatures, creating a painful "illusion" (no tissue injury is caused) in the brain when the cool and warm stimuli are presented collectively. Advancement in objective pain assessment research is limited because the gold standard, the self-reporting pain scale, is highly subjective and only works for alert and cooperative patients. However, the main difficulty for pain studies is the potential harm caused to participants. We have recruited 23 subjects in whom we induced electric pulses and thermal grill (TG) stimulation. The TG effectively induced three different levels of pain, as evidenced by the visual analog scale (VAS) provided by the subjects after each stimulus. Furthermore, objective physiological measurements based on electrodermal activity showed a significant increase in levels as stimulation level increased. We found that VAS was highly correlated with the TG stimulation level. The TG stimulation safely elicited pain levels up to 9 out of 10. The TG stimulation allows for extending studies of pain to ranges of pain in which other stimuli are harmful.