Chronic Alternate-Day Fasting Results in Reduced Diastolic Compliance and Diminished Systolic Reserve in Rats
Chronic Alternate-Day Fasting Results in Reduced Diastolic Compliance and Diminished Systolic Reserve in Rats
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DOI：
10.1016/j.cardfail.2010.05.007
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发表时间：
2010-10-01
影响因子：
6
通讯作者：
Talan, Mark I.
中科院分区：
文献类型：
--
作者：
Ahmet, Ismayil;Wan, Ruiqian;Talan, Mark I.
背景：基于动物实验和少数人体试验的有限数据，隔日禁食（ADF）导致体重减轻，寿命延长，减少糖尿病和心血管疾病的代谢危险因素，并降低年龄相关疾病的患病率。本研究首次全面考察了ADF对大鼠一般心血管健康的长期影响。方法与结果：4月龄雄性Sprague-Dawley大鼠开始给予ADF或继续自由饮食，连续超声心动图随访6个月。在研究结束时进行全面的血流动力学评估，包括联合多巴酚丁胺容量压力测试，并采集心脏进行组织学评估。6个月的ADF饮食减少了9% (P
Background: Based on animal experiments and limited data from the few human trials, alternate-day fasting (ADF) resulted in weight loss, prolonged life, reduced metabolic risk factors for diabetes and cardiovascular diseases, and reduced prevalence of age-related diseases. The present study is the first comprehensive examination of the long-term effects of ADF on general cardiovascular fitness in rats.Methods and Results: Four-month-old male Sprague-Dawley rats were started on ADF or continued on ad libitum diets and followed for 6 months with serial echocardiography. A comprehensive hemodynamic evaluation including a combined dobutamine volume stress test was performed at the end of the study, and hearts were harvested for histological assessment. The 6-month-long ADF diet resulted in a 9% reduction (P