Intentional weight loss and mortality among overweight individuals with diabetes
Intentional weight loss and mortality among overweight individuals with diabetes
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DOI：
10.2337/diacare.23.10.1499
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发表时间：
2000-10-01
期刊：
影响因子：
16.2
通讯作者：
Byers, T
中科院分区：
文献类型：
--
作者：
Williamson, DF;Thompson, TJ;Byers, T
目的 - 评估有意减肥对超重糖尿病患者死亡率的影响。 研究设计和方法 - 我们对参加美国癌症协会癌症预防研究 I 的 4,970 名 4,970 名 40-64 岁超重糖尿病患者进行了为期 12 年的死亡率随访（1959-1972 年）。计算了比率 (RR)，比较总体死亡率和死亡率在有或没有报告有意减肥的个体中，有心血管疾病 (CVD) 或糖尿病的风险。结果 - 34% 的队列中的人报告有意减肥。调整初始 BMI、社会人口统计学因素、健康状况和体力活动后，有意减肥与总死亡率降低 25% 相关（RR = 0.75；95% CI 0.67-0.84），CVD 和糖尿病死亡率降低 28%（RR = 0.72；0.63-0.82）。有意识地减重 20-29 磅与死亡率的最大降低有关（接近 33%）。体重减轻 >70 Ib 与死亡率小幅增加相关。结论 - 在这项针对超重糖尿病患者的观察性研究中，有意识的体重减轻与死亡率的大幅降低相关。
OBJECTIVE - To estimate the effect of intentional weight loss on mortality in overweight individuals with diabetes.RESEARCH DESIGN AND METHODS - We performed a prospective analysis with a 12-year mortality follow-up (1959-1972) of 4,970 overweight individuals with diabetes, 40-64 years of age, who were enrolled in the American Cancer Society's Cancer Prevention Study I. Rate ratios (RRs) were calculated, comparing overall death rates, and death from cardiovascular disease (CVD) or diabetes in individuals with and without reported intentional weight loss.RESULTS - Intentional weight loss was reported by 34% of the cohort. After adjustment for initial BMI, sociodemographic factors, health status, and physical activity, intentional weight loss was associated with a 25% reduction in total mortality (RR = 0.75; 95% CI 0.67-0.84), and a 28% reduction in CVD and diabetes mortality (RR = 0.72; 0.63-0.82). intentional weight loss of 20-29 lb was associated with the largest reductions in mortality (similar to 33%). Weight loss >70 Ib was associated with small increases in mortality.CONCLUSIONS - Intentional weight loss was associated with substantial reductions in mortality in this observational study of overweight individuals with diabetes.