Biologic Correlation of 2-[18F]-Fluoro-2-Deoxy-D-Glucose Uptake on Positron Emission Tomography in Thymic Epithelial Tumors
Biologic Correlation of 2-[18F]-Fluoro-2-Deoxy-D-Glucose Uptake on Positron Emission Tomography in Thymic Epithelial Tumors
复制标题
DOI：
10.1200/jco.2009.27.4662
复制
发表时间：
2010-08-10
影响因子：
45.3
通讯作者：
Yamamoto, Nobuyuki
中科院分区：
文献类型：
--
作者：
Kaira, Kyoichi;Endo, Masahiro;Yamamoto, Nobuyuki
目的利用2-[F-18]-氟-2-脱氧-d -葡萄糖（[F-18]FDG）正电子发射断层扫描（PET）技术预测胸腺上皮肿瘤的恶性分级和分期。然而，对于这种现象还没有令人满意的生物学解释。本研究的目的是探讨[F-18] FDG摄取的潜在生物学机制。患者和方法本研究纳入49例胸腺上皮肿瘤患者，均行[18F] FDG PET。采用免疫组化方法对肿瘤切片进行葡萄糖转运蛋白1 （GLUT1）、葡萄糖转运蛋白3 （GLUT3）、缺氧诱导因子-1 α (HIF-1 α)、血管内皮生长因子（VEGF）、微血管（CD31和CD34）、细胞周期控制标志物（p53）和凋亡标志物（bcl-2）的免疫组化染色。我们还进行了胸腺肿瘤细胞系对[F-18] FDG摄取的体外研究。结果[F-18] FDG摄取与GLUT1 （P < 0.0001）、HIF-1 α (P = 0.0036)、VEGF （P < 0.001）呈正相关
Purpose The usefulness of 2-[F-18]-fluoro-2-deoxy-D-glucose ([F-18]FDG) positron emission tomography (PET) can help predict the grade of malignancy and staging in thymic epithelial tumors. However, no satisfactory biologic explanation exists for this phenomenon. The aim of this study was to investigate the underlying biologic mechanisms of [F-18] FDG uptake.Patients and MethodsForty-nine patients with thymic epithelial tumors who underwent [18F] FDG PET were included in this study. Tumor sections were stained by immunohistochemistry for glucose transporter 1 (GLUT1), glucose transporter 3 (GLUT3), hypoxia-inducible factor-1 alpha (HIF-1 alpha), vascular endothelial growth factor (VEGF), microvessels (CD31 and CD34), cell cycle control marker (p53), and apoptosis marker (bcl-2). We also conducted an in vitro study of [F-18] FDG uptake in a thymic tumor cell line.ResultsThere was a positive correlation between [F-18] FDG uptake and GLUT1 (P < .0001), HIF-1 alpha (P = .0036), VEGF (P