Altered properties of brain white matter structural networks in patients with nasopharyngeal carcinoma after radiotherapy
Altered properties of brain white matter structural networks in patients with nasopharyngeal carcinoma after radiotherapy
复制标题
鼻咽癌患者放疗后脑白质结构网络特性的改变。
DOI：
10.1007/s11682-019-00224-2
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发表时间：
2020-01-03
影响因子：
3.2
通讯作者：
Huang, Ruiwang
中科院分区：
文献类型：
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作者：
Chen, Qinyuan;Lv, Xiaofei;Huang, Ruiwang
以往的神经影像学研究显示，鼻咽癌（NPC）患者在放疗（RT）后数年内会出现放射性脑损伤。这些损伤可能与结构和功能改变有关。然而，鼻咽癌患者在放疗后不同时间，特别是在早期延迟期，脑结构连接的差异仍不清楚。我们采集了三组NPC患者的扩散张量成像（DTI）数据，RT前（RT前）组25例，RT-艾德后（RT-LD后）早期延迟（1-6个月）组22例，RT-LD后（RT-LD后）晚期延迟（>6个月）组33例。然后，我们构建了大脑白色物质（WM）结构网络，并使用图论来比较它们的组间差异。RT-艾德治疗后的鼻咽癌患者与RT治疗前相比，其整体性能下降。我们还检测到节点参数组间差异的节点。RT-艾德后组与RT前组之间的差异主要位于默认模式（DMN）和中央执行网络（CEN）; RT-LD后组与RT前组之间的差异主要位于边缘系统; RT-LD后组与RT-艾德后组之间的差异主要位于DMN。这些发现可能表明，辐射引起的脑损伤开始于早期延迟期，而重组策略开始于晚期延迟期。我们的研究结果可能会提供新的见解，从网络的角度来看，在正常出现的脑组织中的放射性脑损伤的发病机制。
Previous neuroimaging studies revealed radiation-induced brain injury in patients with nasopharyngeal carcinoma (NPC) in the years after radiotherapy (RT). These injuries may be associated with structural and functional alterations. However, differences in the brain structural connectivity of NPC patients at different times after RT, especially in the early-delayed period, remain unclear. We acquired diffusion tensor imaging (DTI) data from three groups of NPC patients, 25 in the pre-RT (before RT) group, 22 in the early-delayed (1-6 months) period (post-RT-ED) group, and 33 in the late-delayed (>6 months) period (post-RT-LD) group. Then, we constructed brain white matter (WM) structural networks and used graph theory to compare their between-group differences. The NPC patients in the post-RT-ED group showed decreased global properties when compared with the pre-RT group. We also detected the nodes with between-group differences in nodal parameters. The nodes that differed between the post-RT-ED and pre-RT groups were mainly located in the default mode (DMN) and central executive networks (CEN); those that differed between the post-RT-LD and pre-RT groups were located in the limbic system; and those that differed between the post-RT-LD and post-RT-ED groups were mainly in the DMN. These findings may indicate that radiation-induced brain injury begins in the early-delayed period and that a reorganization strategy begins in the late-delayed period. Our findings may provide new insight into the pathogenesis of radiation-induced brain injury in normal-appearing brain tissue from the network perspective.