Dietary calcium, vitamin D, and the risk of colorectal cancer
Dietary calcium, vitamin D, and the risk of colorectal cancer
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DOI：
10.3945/ajcn.2008.26195
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发表时间：
2008-12-01
影响因子：
7.1
通讯作者：
Tsugane, Shoichiro
中科院分区：
文献类型：
--
作者：
Ishihara, Junko;Inoue, Manami;Tsugane, Shoichiro
背景：钙和维生素D对预防结直肠癌有潜在的保护作用。目的：在一项对日本中年男性和女性进行的大型前瞻性队列研究中，我们调查了饮食中钙和维生素D的摄入量与结直肠癌风险的关系。设计：1995-1999年至2004年底，日本公共卫生中心对74 639名受试者(35 194名男性和39 445名女性)进行了跟踪调查，在此期间新发现了761例结直肠癌患者(男性464名，女性297名)。膳食营养素摄入量采用138项自填式食物频率问卷进行计算，男性膳食钙摄入量最高五分之一与最低五分之一的危险比为0.71(95%CI：0.52，0.98)。在第二个五分位数的受试者中，这种关联性似乎显著降低，没有明确的进一步的剂量-反应关系(趋势P：0.09)。在女性中没有发现任何关联。男性和女性的膳食维生素D摄入量都没有统计学意义上的相关性，尽管这两种营养素的膳食摄入量最高组的男性比饮食摄入量最低组的男性风险更低。结论：这些发现表明，在饮食钙摄入量相对较低的日本中年男性中，饮食中钙摄入量较高的人患结直肠癌的风险可能会降低。尽管维生素D和结直肠癌风险没有关联，但钙和维生素D之间的修饰对结直肠癌风险的潜在影响
Background: Calcium and vitamin D have a potential protective effect against colorectal cancer.Objective: We investigated the association of dietary intake of calcium and vitamin D with the risk of colorectal cancer in a large prospective cohort study of middle-aged Japanese men and women.Design: A total of 74 639 subjects (35 194 men and 39 445 women) who participated in the Japan Public Health Center-based Prospective Study were followed from 1995-1999 to the end of 2004, during which time 761 cases of colorectal cancer (464 men, 297 women) were newly identified. Dietary intake of nutrients was calculated with the use of a 138-item self-administered food-frequency questionnaire.hazard ratio in the highest quintile of dietary calcium intake compared with the lowest was 0.71 (95% CI: 0.52, 0.98) among men. The association appeared to decrease considerably among subjects in the second quintile without a clear further dose-response relation (P for trend: 0.09). No association was seen among women. No statistically significant association with dietary vitamin D intake was seen in either men or women, although men in the highest dietary intake group of both nutrients had a lower risk than did men in the lowest group.Conclusions: These findings indicate a potential decrease in the risk of colorectal cancer with higher dietary intake of calcium among middle-aged Japanese men, who have a relatively low dietary intake of calcium. Although vitamin D and colorectal cancer risk were not associated, potential effect modification between calcium and vitamin D on the risk of colorectal