STUDY OF RENIN-ANGIOTENSIN SYSTEM IN NEWBORN INFANTS
STUDY OF RENIN-ANGIOTENSIN SYSTEM IN NEWBORN INFANTS
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DOI：
10.1016/s0022-3476(72)80005-2
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发表时间：
1972-01-01
影响因子：
5.1
通讯作者：
RICE, TW
中科院分区：
文献类型：
--
作者：
KOTCHEN, TA;WALTERS, DR;RICE, TW
在新生儿中研究了肾素-血管紧张素系统。在分娩后的前六天内，可生物测定和可免疫测定的肾素活性升高。在 3 至 6 周龄时，尽管肾素活性高于成年对照受试者，但仍低于出生后第一周。分娩时脐带血肾素值高于母体肾素值。六天以下的婴儿以及 3 至 6 周大的婴儿的肾素底物浓度升高。肾素-血管紧张素系统活性的增强可能导致新生儿肾血管阻力增加和肾血流动力学改变。
The renin-angiotensin system was studied in newborn infants. Bioassayable andimmunoassayable renin activities were elevated during the first six days after delivery. At 3 to 6 weeks of age, although elevated above that in adult control subjects, renin activity was lower than in the first postnatal week. Cord blood renin values were greater than those for maternal renin during labor. Renin substrate concentration was elevated in infants less than six days of age and also in 3- to 6-week-old infants. The enhanced activity of the renin-angiotensin system may contribute to the increased renal vascular resistance and the altered renal hemodynamics that occur in the newborn infant.