Influenza Virus Database (IVDB): an integrated information resource and analysis platform for influenza virus research.
Influenza Virus Database (IVDB): an integrated information resource and analysis platform for influenza virus research.
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流感病毒数据库（IVDB）：流感病毒研究的综合信息资源和分析平台。
DOI：
10.1093/nar/gkl779
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发表时间：
2007-01
影响因子：
14.9
通讯作者：
中科院分区：
文献类型：
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作者：
高致病性禽流感的频繁爆发和可用于比较分析的数据的不断增加需要一个专门针对流感病毒的中央数据库。我们建立了流感病毒数据库（IVDB），以整合信息，并为病毒的遗传，基因组和系统发育研究创建分析平台。IVDB托管了北京基因组研究所（BIG）生成的甲型流感病毒全基因组序列，并经过专家注释后整理了所有其他已发表的IV序列。我们的Q-Filter系统根据序列内容和完整性将所有核苷酸序列分为七类。IVDB为病毒基因组、基因、遗传多态性和系统发育关系的比较分析提供了一系列工具和查看器。开发了一个搜索系统，供用户通过设置搜索选项检索不同数据类型的组合。为了便于分析全球病毒传播和进化，已经开发了IV序列分布工具（IVDT），以显示选定病毒基因型的全球地理分布，并将基因组数据与流行病学数据相结合。整合BLAST、多重序列比对和系统发育分析工具进行在线数据分析。此外，IVDB提供即时访问预先计算的IV基因和蛋白质的比对和多态性，并将结果呈现为SNP分布图和次要等位基因分布。IVDB可在以下网址公开获取：
Frequent outbreaks of highly pathogenic avian influenza and the increasing data available for comparative analysis require a central database specialized in influenza viruses (IVs). We have established the Influenza Virus Database (IVDB) to integrate information and create an analysis platform for genetic, genomic, and phylogenetic studies of the virus. IVDB hosts complete genome sequences of influenza A virus generated by Beijing Institute of Genomics (BIG) and curates all other published IV sequences after expert annotation. Our Q-Filter system classifies and ranks all nucleotide sequences into seven categories according to sequence content and integrity. IVDB provides a series of tools and viewers for comparative analysis of the viral genomes, genes, genetic polymorphisms and phylogenetic relationships. A search system has been developed for users to retrieve a combination of different data types by setting search options. To facilitate analysis of global viral transmission and evolution, the IV Sequence Distribution Tool (IVDT) has been developed to display the worldwide geographic distribution of chosen viral genotypes and to couple genomic data with epidemiological data. The BLAST, multiple sequence alignment and phylogenetic analysis tools were integrated for online data analysis. Furthermore, IVDB offers instant access to pre-computed alignments and polymorphisms of IV genes and proteins, and presents the results as SNP distribution plots and minor allele distributions. IVDB is publicly available at