Complex role of HIF in cancer: the known, the unknown, and the unexpected.
Complex role of HIF in cancer: the known, the unknown, and the unexpected.
复制标题
DOI：
10.2147/hp.s50651
复制
发表时间：
2014
期刊：
影响因子：
--
通讯作者：
Huang LE
中科院分区：
文献类型：
--
作者：
Tiburcio PD;Choi H;Huang LE
肿瘤缺氧长期以来被认为是恶性进展和治疗抗性的驱动力。低氧诱导转录因子（HIF）的发现极大地促进了我们对癌细胞如何通过糖酵解刺激维持生物能量来科普低氧应激的理解。然而，直到最近，为什么增殖性癌细胞选择有氧糖酵解（一种能量效率低下的葡萄糖代谢过程）仍然令人困惑。此外，HIF在癌症中的作用也变得复杂。在这篇综述中，我们强调了最近在癌症代谢方面的突破性发现，对HIF的复杂作用提出了合理的解释，并强调了癌症生物学中的剩余问题。
Tumor hypoxia has long been recognized as a driving force of malignant progression and therapeutic resistance. The discovery of hypoxia-inducible transcription factors (HIFs) has greatly advanced our understanding of how cancer cells cope with hypoxic stress by maintaining bioenergetics through the stimulation of glycolysis. Until recently, however, it remained perplexing why proliferative cancer cells opt for aerobic glycolysis, an energy-inefficient process of glucose metabolism. Furthermore, the role of HIF in cancer has also become complex. In this review, we highlight recent groundbreaking findings in cancer metabolism, put forward plausible explanations to the complex role of HIF, and underscore remaining issues in cancer biology.