Computer-aided analysis with Image J for quantitatively assessing psoriatic lesion area
Computer-aided analysis with Image J for quantitatively assessing psoriatic lesion area
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DOI：
10.1111/srt.12211
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发表时间：
2015-11-01
影响因子：
2.2
通讯作者：
Zhao, Y.
中科院分区：
文献类型：
--
作者：
Sun, Z.;Wang, Y.;Zhao, Y.
背景/目的体表面积在确定银屑病的严重程度中是重要的。然而，仍然需要客观、可靠和实用的方法来实现这一目的。我们进行了计算机图像分析（CIA）的银屑病面积使用的图像J免费软件，以确定这种方法是否可以用于客观评价银屑病area.MethodsFifteen银屑病患者随机接受阿达木单抗或安慰剂治疗的临床试验。每次访视时，由两名医生估计每个身体部位的银屑病面积（E法），并拍摄标准照片。用CIA半自动阈值选择法（T法）或手动阈值选择法（M法，金标准）对图片中银屑病面积进行评估。结果T法、E法与M法的相关性均较强，T法与M法的相关性略强。T-和E-方法在评价者之间具有良好的一致性。3种方法均能检测出治疗后银屑病皮损面积的变化，而E-法有高估的倾向。结论CIA结合Image J免费软件对银屑病皮损面积进行定量评估是可靠的、可行的。
Background/aimsBody surface area is important in determining the severity of psoriasis. However, objective, reliable, and practical method is still in need for this purpose. We performed a computer image analysis (CIA) of psoriatic area using the image J freeware to determine whether this method could be used for objective evaluation of psoriatic area.MethodsFifteen psoriasis patients were randomized to be treated with adalimumab or placebo in a clinical trial. At each visit, the psoriasis area of each body site was estimated by two physicians (E-method), and standard photographs were taken. The psoriasis area in the pictures was assessed with CIA using semi-automatic threshold selection (T-method), or manual selection (M-method, gold standard). The results assessed by the three methods were analyzed with reliability and affecting factors evaluated.ResultsBoth T- and E-method correlated strongly with M-method, and T-method had a slightly stronger correlation with M-method. Both T- and E-methods had a good consistency between the evaluators. All the three methods were able to detect the change in the psoriatic area after treatment, while the E-method tends to overestimate.ConclusionThe CIA with image J freeware is reliable and practicable in quantitatively assessing the lesional of psoriasis area.