Molecular and phenotypic biomarkers of aging.
Molecular and phenotypic biomarkers of aging.
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DOI：
10.12688/f1000research.10692.1
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发表时间：
2017
期刊：
影响因子：
--
通讯作者：
Han JJ
中科院分区：
文献类型：
--
作者：
Xia X;Chen W;McDermott J;Han JJ
同样年龄的人可能不会以同样的速度衰老。衰老的定量生物标志物是测量生理年龄、评估“健康衰老”程度以及潜在地预测个体的健康寿命和寿命的有价值的工具。鉴于衰老过程的复杂性，衰老的生物标志物是多层次和多方面的。在这里，我们回顾了衰老的表型和分子生物标志物。识别和使用衰老的生物标志物，以改善人类健康，预防年龄相关疾病，并延长健康寿命，现在促进了快速增长的能力，多层次的横截面和纵向数据采集，存储和分析，特别是与一般人群相关的数据。结合人工智能和机器学习技术，可靠的衰老生物标志物面板将具有改善老龄化社会人类健康的巨大潜力。
Individuals of the same age may not age at the same rate. Quantitative biomarkers of aging are valuable tools to measure physiological age, assess the extent of ‘healthy aging’, and potentially predict health span and life span for an individual. Given the complex nature of the aging process, the biomarkers of aging are multilayered and multifaceted. Here, we review the phenotypic and molecular biomarkers of aging. Identifying and using biomarkers of aging to improve human health, prevent age-associated diseases, and extend healthy life span are now facilitated by the fast-growing capacity of multilevel cross-sectional and longitudinal data acquisition, storage, and analysis, particularly for data related to general human populations. Combined with artificial intelligence and machine learning techniques, reliable panels of biomarkers of aging will have tremendous potential to improve human health in aging societies.