Passive stretches protect skeletal muscle of adult and old mice from lengthening contraction-induced injury.
Passive stretches protect skeletal muscle of adult and old mice from lengthening contraction-induced injury.
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被动伸展可以保护成年和老年小鼠的骨骼肌免受延长收缩引起的损伤。
DOI：
10.1093/gerona/58.7.b592
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发表时间：
2003
期刊：
影响因子：
--
通讯作者：
Brooks,SusanV
中科院分区：
文献类型：
--
作者：
Koh,TimothyJ;Peterson,JenniferM;Pizza,FrancisX;Brooks,SusanV
我们测试了这样的假设：单次被动拉伸或等长收缩训练可以保护老年小鼠的趾长伸肌免受收缩引起的损伤。在成年和老年小鼠中，延长收缩会导致力（约 70%–80%）和明显损伤的纤维数量（约 15%–20%）相似的减少，但与成年小鼠相比，老年小鼠的炎症细胞积累量比未治疗的对照值高出两倍。对于这两个年龄段的人来说，与未经训练的肌肉相比，事先进行被动伸展训练可以将受伤后的力量提高近两倍，并将受伤的纤维减少一半。在老年小鼠中，被动拉伸或等长收缩训练可减少延长收缩后炎症细胞的积累多达三分之二，但在成年小鼠中则不然。数据表明，被动拉伸可以在一定程度上保护老年小鼠免受收缩引起的损伤，并且炎症细胞的积累与力量不足和受伤纤维的数量没有很强的相关性。
We tested the hypothesis that a single bout of training with passive stretches or isometric contractions protects the extensor digitorum longus muscle in old mice from contraction-induced injury. Lengthening contractions produced similar decreases in force (∼70%–80%) and numbers of overtly injured fibers (∼15%–20%) in adult and old mice, but twofold greater inflammatory cell accumulation above untreated control values in old versus adult mice. For both age groups, prior training with passive stretches improved postinjury force almost twofold compared with untrained muscles and reduced injured fibers by one half. Training with passive stretches or isometric contractions reduced inflammatory cell accumulation following lengthening contractions by as much as two thirds in old mice, but not in adult mice. The data indicate that passive stretches provide some protection against contraction-induced injury in old mice, and that accumulation of inflammatory cells does not correlate strongly with force deficit and number of injured fibers.
影响因子：
4.3
作者：
H. Sambrook
通讯作者：
H. Sambrook