Sleep-dependent synaptic down-selection (I): modeling the benefits of sleep on memory consolidation and integration
Sleep-dependent synaptic down-selection (I): modeling the benefits of sleep on memory consolidation and integration
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DOI：
10.3389/fneur.2013.00143
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发表时间：
2013-01-01
影响因子：
3.4
通讯作者：
Tononi, Giulio
中科院分区：
文献类型：
--
作者：
Nere, Andrew;Hashmi, Atif;Tononi, Giulio
睡眠有助于巩固程序性记忆和陈述性记忆，有助于提炼主旨，有助于新旧记忆的整合，降低学习能力。人们通常认为，这种有益的效果是由于睡眠中神经回路的重新激活，以进一步加强在醒着时修改的突触，或将记忆转移到大脑的不同部分。一种不同的可能性是，睡眠可能不是通过进一步加强突触而有益于记忆，而是通过重整化突触强度来恢复觉醒后突触的净增强后的细胞内稳态。以这种方式，依赖睡眠的神经回路的重新激活可能会导致竞争性地向下选择不经常激活的突触，这些突触与记忆的整体组织不太匹配。通过计算机模拟，我们发现突触向下选择原则上足以解释睡眠对程序性和陈述性记忆的巩固、主旨提取和新旧记忆整合的有益影响，从而解决可塑性-稳定性两难问题。
Sleep can favor the consolidation of both procedural and declarative memories, promote gist extraction, help the integration of new with old memories, and desaturate the ability to learn. It is often assumed that such beneficial effects are due to the reactivation of neural circuits in sleep to further strengthen the synapses modified during wake or transfer memories to different parts of the brain. A different possibility is that sleep may benefit memory not by further strengthening synapses, but rather by renormalizing synaptic strength to restore cellular homeostasis after net synaptic potentiation in wake. In this way, the sleep dependent reactivation of neural circuits could result in the competitive down-selection of synapses that are activated infrequently and fit less well with the overall organization of memories. By using computer simulations, we show here that synaptic down-selection is in principle sufficient to explain the beneficial effects of sleep on the consolidation of procedural and declarative memories, on gist extraction, and on the integration of new with old memories, thereby addressing the plasticity-stability dilemma.