Incidence and short-term outcome of acute lung injury in mechanically ventilated children
Incidence and short-term outcome of acute lung injury in mechanically ventilated children
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DOI：
10.1183/09031936.03.00003303
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发表时间：
2003-12-01
影响因子：
24.3
通讯作者：
Bos, AP
中科院分区：
文献类型：
--
作者：
Dahlem, P;van Aalderen, WMC;Bos, AP
本研究的目的是确定1998年1月1日至2000年1月1日在儿科重症监护病房（PICU）接受机械通气的儿童急性肺损伤（ALI）的发生率和短期预后。44例（9.9%）诊断为ALI。其中，79.5%发生了急性呼吸窘迫综合征（ARDS）：54.5%（24/44）在入选时符合ARDS标准，25%（11/44）在入选后符合。PICU中ALI的死亡率为27.3%（12/44），ARDS亚组中的死亡率为31.4%（11/35）。在12名死亡的儿童中，11名患有ARDS;主要死亡原因是脑损伤（12人中有7人）。急性肺损伤和急性呼吸窘迫综合征是儿科重症监护病房中的罕见疾病，死亡率很高。大多数急性肺损伤的儿童发展为急性呼吸窘迫综合征。在急性呼吸窘迫综合征亚组中，死亡率高于急性肺损伤非急性呼吸窘迫综合征亚组。进一步的研究应确认预后因素（例如，预后参数），以预测结果。
The aim of this study was to determine the incidence and short-term outcome of mechanically ventilated children suffering from acute lung injury (ALI) on a paediatric intensive care unit (PICU).Between January, 1 1998 and January 1 2000, all mechanically ventilated children were evaluated using the criteria of an American-European Consensus Conference.Of the 443 children eligible for analysis, 44 (9.9%) were diagnosed as suffering from ALI. Of these, 79.5% developed the acute respiratory distress syndrome (ARDS): 54.5% (24 of 44) fulfilled the ARDS criteria at inclusion and 25% (11 of 44) later. PICU mortality for ALI was 27.3% (12 of 44) and within the ARDS subgroup 31.4% (11 of 35). Of the 12 children who died, 11 had ARDS; the main cause of death as cerebral damage (seven of 12).Acute lung injury and acute respiratory distress syndrome are rare diseases on a paediatric intensive care unit with a high mortality. Most of the children with acute lung injury develop acute respiratory distress syndrome. In the acute respiratory distress syndrome subgroup, mortality is higher than in the acute lung injury nonacute respiratory distress syndrome subgroup. Further investigations should confirm prognostic factors (e.g. respirators parameters) for prediction of outcome.