Aspirin attenuates spontaneous recurrent seizures and inhibits hippocampal neuronal loss, mossy fiber sprouting and aberrant neurogenesis following pilocarpine-induced status epilepticus in rats
Aspirin attenuates spontaneous recurrent seizures and inhibits hippocampal neuronal loss, mossy fiber sprouting and aberrant neurogenesis following pilocarpine-induced status epilepticus in rats
复制标题
阿司匹林可减轻毛果芸香碱诱导的大鼠癫痫持续状态后自发性复发性癫痫发作并抑制海马神经元损失、苔藓纤维发芽和异常神经发生
DOI：
10.1016/j.brainres.2012.05.058
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发表时间：
2012-08-21
期刊：
影响因子：
2.9
通讯作者：
Jiang, Wen
中科院分区：
文献类型：
--
作者：
Ma, Lei;Cui, Xiao-Li;Jiang, Wen
越来越多的数据表明，炎症可能有助于实验模型以及人类癫痫的发生。然而，抗炎治疗是否可以预防癫痫仍然存在争议。在此，我们研究了阿司匹林（一种非选择性环氧合酶（考克斯）抑制剂）在锂-匹罗卡品诱导的癫痫持续状态（SE）大鼠模型中的抗癫痫作用和可能的机制。癫痫大鼠在SE终止后0 h、3 h或24 h用阿司匹林（20 mg/kg）治疗，随后每天治疗一次，持续20天。我们发现，阿司匹林治疗显着减少的频率和持续时间的自发复发性癫痫发作在慢性癫痫阶段。SE后5周的海马神经元丢失在阿司匹林给药后的CA 1、CA 3和门部也有所减弱。此外，阿司匹林阻止了新生颗粒细胞的异常迁移和肺门基底树突的形成。在SE后3小时或24小时开始用阿司匹林治疗也抑制了苔藓纤维发芽的发展。这些发现表明，阿司匹林干预损伤后癫痫发生过程的时间窗口可能相对较宽。阿司匹林可能作为一种潜在的治疗慢性癫痫易感个体。(C)2012爱思唯尔有限公司版权所有。
Accumulating data suggest that inflammation may contribute to epileptogenesis in experimental models as well as in humans. However, whether anti-inflammatory treatments can prevent epileptogenesis still remains controversial. Here, we examined the anti-epileptogenic effect and possible mechanisms of aspirin, a non-selective Cyclooxygenase (COX) inhibitor, in a rat model of lithium-pilocarpine-induced status epilepticus (SE). Epileptic rats were treated with aspirin (20 mg/kg) at 0 h, 3 h, or 24 h after the termination of SE, followed by once daily treatment for the subsequent 20 days. We found that aspirin treatment significantly reduced the frequency and duration of spontaneous recurrent seizures during the chronic epileptic phase. Hippocampal neuronal loss five weeks after SE was also attenuated in the CA1, CA3 and hilus following aspirin administration. Furthermore, the aberrant migration of newly generated granule cells and the formation of hilar basal dendrites were prevented by aspirin. Treatment with aspirin starting at 3 h or 24 h after SE also suppressed the development of mossy fiber sprouting. These findings suggest the possibility of a relative broad time-window for aspirin intervention in the epileptogenic process after injury. Aspirin may serve as a potential adjunctive therapy for individuals susceptible to chronic epilepsy. (C) 2012 Elsevier B.V. All rights reserved.