Evaluation of the Relationship between the Znf804A Single Nucleotide Polymorphism Rs1344706 a/c Variant and Schizophrenia Subtype in Han Chinese Patients
Evaluation of the Relationship between the Znf804A Single Nucleotide Polymorphism Rs1344706 a/c Variant and Schizophrenia Subtype in Han Chinese Patients
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DOI：
10.2190/pm.45.3.f
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发表时间：
2013-04
期刊：
影响因子：
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通讯作者：
Yongfeng Yang;Wenqiang Li;Ge Yang;B. Xiao;Xiujuan Wang;Minli Ding;Jing-yuan Zhao;Xueqin Song;W. Yue;Dai Zhang;Hongxing Zhang;L. Lv
中科院分区：
文献类型：
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作者：
Yongfeng Yang;Wenqiang Li;Ge Yang;B. Xiao;Xiujuan Wang;Minli Ding;Jing-yuan Zhao;Xueqin Song;W. Yue;Dai Zhang;Hongxing Zhang;L. Lv
目的：最近的全基因组关联研究（GWASs）评估了精神分裂症（SZ）与ZNF804A基因，特别是单核苷酸多态性（SNP） rs1344706之间的关系，但得出了相互矛盾的结果。精神分裂症是一种异质性疾病，因此这种关联可能仅限于特定的SZ亚型，而群体异质性可能掩盖了ZNF804A等位基因变异对SZ风险的贡献。因此，我们在大量汉族患者人群中评估了rs1344706与不同临床SZ亚型之间的关系。方法：采用聚合酶链反应限制性片段长度多态性（PCR-RFLPs）对1025例SZ患者和977例健康对照进行rs1344706基因型检测。临床SZ亚型包括偏执型、紧张型、分裂型和未分化型，诊断依据《精神障碍诊断与统计手册-第四版IV》（DSM-IV）。结果：对照组与总人群（A、b、C, χ2 = 4.339、2.994;p = 0.227、0.087）、偏执型SZ患者（χ2 = 2.053、0.002;p = 0.562、0.973）的基因型和等位基因频率差异均无统计学意义。基因型频率与SZ亚型有显著相关性（χ2 = 12.632, p = 0.049）。结论：我们没有发现ZNF804A SNP rs1344706是SZ易感位点的证据。然而，先前的关联研究结果相互矛盾可能是由于不同患者SZ亚型之间的遗传异质性。
Objective: Recent genome wide association studies (GWASs) assessing the relationship between schizophrenia (SZ) and the ZNF804A gene, particularly the single nucleotide polymorphism (SNP) rs1344706, have yielded conflicting results. Schizophrenia is a heterogeneous disorder, so it is possible that an association may be restricted to specific SZ subtypes and that population heterogeneity may obscure a contribution of ZNF804A allelic variation to SZ risk. We thus evaluated the association between rs1344706 and different clinical SZ subtypes in a large Han Chinese patient population. Method: The rs1344706 genotype was determined in 1,025 SZ patients and 977 healthy controls using polymerase chain reaction restriction fragment length polymorphisms (PCR-RFLPs). The clinical SZ subtypes included paranoid, catatonic, disintegrated, and undifferentiated, diagnosed according to the Diagnostic and Statistical Manual of Mental Disorders-Fourth Edition IV (DSM-IV). Results: No significant differences in genotype and allele frequencies were found between controls and either the total SZ population (A > C, χ2 = 4.339, 2.994; p = 0.227, 0.087, respectively) or paranoid SZ patients (χ2 = 2.053, 0.002; p = 0.562, 0.973, respectively). However, there was a significant association between genotype frequency and SZ subtype (χ2 = 12.632, p = 0.049). Conclusions: We found no evidence that the ZNF804A SNP rs1344706 is a susceptibility locus for SZ. However, conflicting results from previous association studies may be due to genetic heterogeneity between different patient SZ subtypes.