Serum Inflammatory Markers in Obstructive Sleep Apnea: A Meta-Analysis
Serum Inflammatory Markers in Obstructive Sleep Apnea: A Meta-Analysis
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DOI：
10.5664/jcsm.3070
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发表时间：
2013-01-01
影响因子：
4.3
通讯作者：
Loomba, Rohit
中科院分区：
文献类型：
--
作者：
Nadeem, Rashid;Molnar, Janos;Loomba, Rohit
研究目的：阻塞性睡眠呼吸暂停（OSA）与心血管和脑血管疾病发病率增加有关。持续的炎症反应在这种关联中起着重要作用。多个小规模的研究解决了OSA中炎症标志物的概况，因此我们进行了荟萃分析。方法：使用PubMed、科克伦和EMBASE数据库对1968年至2011年的医学文献进行系统性综述，使用关键词阻塞性睡眠呼吸暂停、C反应蛋白、肿瘤坏死因子α（TNF-α）、白细胞介素6（IL-6）、白细胞介素8（IL-8）、细胞间粘附分子（ICAM）、血管细胞粘附分子（VCAM）和选择素。入选标准为：英文全文;成人研究;至少一种目标标志物的报告值;至少有两个单独的组（OSA受试者和对照组）; OSA定义为AHI = 5/h。对512项研究进行了审查，其中51项研究进行了汇总分析（30项CRP研究，19项TNF-α研究，8项ICAM研究，18项IL-6研究，6项VCAM研究和5项选择素研究）。与对照组相比，OSA患者的炎症标志物水平较高。CRP、TNF-α、IL-6、IL-8、ICAM、选择素和VCAM.Conclusions的标准化合并平均差异分别为1.77、1.03、2.16、4.22、2.93、1.45和2.08。
Study Objectives: Obstructive sleep apnea (OSA) has been linked to and is associated with increased cardiovascular and cerebrovascular morbidity. Ongoing inflammatory responses play an important role in this association. Multiple small size studies addressing the profile of the inflammatory markers in OSA are available therefore we performed a meta-analysis.Methods: Systematic review of medical literature was conducted using PubMed, Cochrane, and EMBASE databases from 1968 to 2011 by utilizing the key words obstructive sleep apnea, C-Reactive protein, tumor necrosis factor alpha (TNF-a), interleukin 6 (IL-6), interleukin 8 (IL-8), intercellular adhesion molecule (ICAM), vascular cell adhesion molecule (VCAM) and Selectins. Inclusion criteria were: full text English articles; studies with adult population; reported values for at least one of the markers of interest; with at least two separate groups (subjects with OSA and control group); OSA was defined as AHI of = 5/h.0Results: Five hundred and twelve studies were reviewed for inclusion with 51 studies pooled for analysis (30 studies for CRP, 19 studies for TNF-a, 8 studies for ICAM, 18 studies for IL-6, six studies for VCAM and 5 studies for Selectins). The levels of inflammatory markers were higher in patients with OSA compared to control group. Standardized pooled Mean differences were calculated to be 1.77 for CRP, 1.03 for TNF-a, 2.16 for IL-6, 4.22 for IL-8, 2.93 for ICAM, 1.45 for Selectins and 2.08 for VCAM.Conclusions: In this meta-analysis, the levels of systemic inflammatory markers were found to be higher in OSA patients compared to control subjects.